Background and Purpose The adenosine A₃ receptor (A₃R) belongs to a family of four adenosine receptor (AR) subtypes which all play distinct roles throughout the body. A₃R antagonists have been described as potential treatments for numerous diseases including asthma. Given the similarity between ARs orthosteric binding sites, obtaining highly selective antagonists is a challenging but critical task.

中文翻译：

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新型腺苷受体A3R拮抗剂的药理特性

背景和目的腺苷A ₃受体（A ₃ R）属于四个腺苷受体（AR）亚型的家族，它们在整个人体中都扮演着不同的角色。阿₃ - [R拮抗剂已被描述为用于许多疾病，包括哮喘潜在的治疗方法。鉴于ARs正构结合位点之间的相似性，获得高度选择性的拮抗剂是一项艰巨而关键的任务。