BACKGROUND and AIMS Extra-hepatic biliary atresia (BA) is a pediatric liver disease with no approved medical therapy. Recent studies using human samples and experimental modeling suggest that glutathione redox metabolism and heterogeneity play a role in disease pathogenesis. We sought to dissect the mechanistic basis of liver redox variation and explore how other stress responses affect cholangiocyte injury in BA.

中文翻译：

---

氧化还原和蛋白质稳态失衡是毒素诱导的胆道闭锁的危险因素和治疗目标

背景与目的肝外胆源性闭锁（BA）是一种未经批准的药物治疗的小儿肝病。最近使用人体样品和实验模型进行的研究表明，谷胱甘肽氧化还原代谢和异质性在疾病发病机理中起作用。我们试图剖析肝脏氧化还原变化的机制基础，并探讨其他应激反应如何影响BA中的胆管细胞损伤。