$\beta$ -aescin is a versatile biosurfactant extracted from the seeds of the horse chestnut tree Aesculus hippocastanum with anti-cancer potential and is commonly used in the food and pharmaceutical and cosmetic industries. In this article, wide-angle X-ray scattering (WAXS) is used in order to study the modifications of the structural parameters at the molecular scale of lipid bilayers in the form of bicelles composed of 1,2-dimyristoyl-sn-glycero-3-phosphocholine (DMPC) and the triterpenoid saponin $\beta$ -aescin. In particular, the impact on the cooperative phase transition and the structural parameters of the DMPC bilayers at different compositions and temperatures is of special interest. Moreover, we show how cholesterol and the non-steroidal anti-inflammatory drug (NSAID) ibuprofen modulate the structural parameters of the $\beta$ -aescin-DMPC assemblies on a molecular scale. Ibuprofen and cholesterol interact with different parts of the bilayer, namely the head-region in the former and the tail-region in the latter case allowing for specific molecular packing and phase formation in the binary and ternary mixtures.

中文翻译：

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胆固醇和布洛芬对DMPC-β-七叶皂素双细胞的影响：随温度变化的广角X射线散射研究

$\beta$ -七叶皂苷是从七叶树七叶树的种子中提取的一种多功能生物表面活性剂，具有抗癌潜力，通常用于食品，制药和化妆品行业。在本文中，使用广角X射线散射（WAXS）来研究脂质双层分子结构上以1,2-二肉豆蔻酰基-sn-甘油- 3-磷酸​​胆碱（DMPC）和三萜皂苷 $\beta$ -曙红。特别地，在不同的组成和温度下对协同相变和DMPC双层的结构参数的影响是特别令人关注的。此外，我们还展示了胆固醇和非甾体抗炎药（NSAID）布洛芬如何调节胆固醇的结构参数 $\beta$ -曙红-DMPC分子规模组装。布洛芬和胆固醇与双层分子的不同部分相互作用，即前者的头部区域和后者的尾部区域，允许二元和三元混合物中发生特定的分子堆积和相形成。