The replenishment of specialized cells depends on the activity of stem cells. Recent advances in stem cell research have shown that the germline stem cells (GSCs) in Drosophila melanogaster can increase their mitotic activity in response to mating. Here, we show that this ability to respond to mating is eliminated if the males are mutant for the ABC transporter, White, the genetic background for a plethora of fly lines. Furthermore, we were not able to reproduce previous findings that female flies increase their GSC numbers and mitotic activity upon mating. Our findings underline the importance of careful experimental design and control specimen.

中文翻译：

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遗传背景和性别对果蝇交配反应中有丝分裂指数增加的影响

专门细胞的补充取决于干细胞的活性。干细胞研究的最新进展表明，果蝇的种系干细胞（GSC）可以响应交配而增加其有丝分裂活性。在这里，我们表明，如果雄性是ABC转运蛋白白色的突变体，则这种对交配的反应能力就被消除了。此外，我们无法重现以前的发现，即雌蝇在交配时会增加其GSC数量和有丝分裂活性。我们的发现强调了仔细进行实验设计和对照标本的重要性。