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Sperm telomere length correlates with blood telomeres and body size in red‐sided garter snakes, Thamnophis sirtalis parietalis
Journal of Zoology ( IF 2 ) Pub Date : 2020-05-16 , DOI: 10.1111/jzo.12789
N. Rollings 1 , H. L. Waye 2 , R. W Krohmer 3 , E. J. Uhrig 4 , R. T. Mason 4 , M. Olsson 5, 6 , C. M. Whittington 1 , C. R. Friesen 6, 7
Affiliation  

Telomeres, tandem repeats of TTAGGG at the ends of chromosomes, are highly dynamic structures that shorten in response to a variety of factors, including organismal stress and tissue‐specific growth rates. Cell turnover rates are frequently linked to their functions, resource availability and telomere dynamics. Using male red‐sided garter snakes, Thamnophis sirtalis parietalis, as a model, we investigated the relationship between telomere length in sperm cells, blood cells telomere length and a growth proxy (age‐adjusted body length and mass). This relationship is interesting because snakes exhibit indeterminate growth and because these garter snakes have a dissociated reproductive cycle where spermatogenesis occurs months prior to the mating season. In this study, we determined sperm telomere length (STL) and male age using qPCR and skeletochronology, respectively. Sperm telomere length correlated positively with snout–vent length (SVL) and with age‐adjusted SVL as a proxy for growth rate (residuals of size against age regression, hereafter growth), but not with age. Although an individual’s STL is correlated with blood telomere length (BTL), sperm telomeres are 60% longer than blood telomeres. In previous work, we have shown that BTL is shorter in older males and unrelated to SVL or any growth rate proxies. We hypothesized that STL is related to growth and SVL because growth and sperm production both occur during summer when resources are most abundant and stress lowest. This study is the first to compare telomere dynamics between cell types in a snake and supports growing evidence that telomere dynamics may be highly tissue‐specific and driven by the life‐history strategy of an organism.

中文翻译:

红边短袜蛇Thamnophis sirtalis parietalis的精子端粒长度与血液端粒和体型相关

端粒是TTAGGG在染色体末端的串联重复序列,是高度动态的结构,可对多种因素(包括机体压力和组织特异性生长速率)作出反应而缩短。细胞周转率通常与其功能,资源可用性和端粒动力学相关。使用雄性红袜带蛇,Thamnophis sirtalis parietalis作为模型,我们研究了精子细胞端粒长度,血细胞端粒长度与生长代用品(年龄调整后的体重和体重)之间的关系。这种关系是有趣的,因为蛇表现出不确定的生长,并且因为这些吊袜带蛇的繁殖周期解离,其中生精发生在交配季节之前的几个月。在这项研究中,我们分别使用qPCR和骨骼年代学方法确定了精子端粒长度(STL)和男性年龄。精子端粒长度与口鼻长度(SVL)和经年龄调整的SVL呈正相关,而SVL代表增长速率(大小相对于年龄回归的残差,此后称为增长),但与年龄无关。尽管一个人的STL与血端粒长度(BTL)相关,但精子端粒比血端粒长60%。在以前的工作中,我们已经证明,年龄较大的男性BTL较短,并且与SVL或任何增长率的代理无关。我们假设STL与生长和SVL有关,因为生长和精子生产都发生在夏季,那时资源最丰富,压力最低。这项研究是首次比较蛇的细胞类型之间的端粒动力学,并支持越来越多的证据表明端粒动力学可能是高度组织特异性的,并且受生物的生命历史策略驱动。
更新日期:2020-05-16
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