Short‐wave infrared hyperspectral imaging is applied to diagnose and monitor a case of allergic contact dermatitis (ACD) due to poison ivy exposure in one subject. This approach directly demonstrates increased tissue fluid content in ACD lesional skin with a spectral signature that matches the spectral signature of intradermally injected normal saline. The best contrast between the affected and unaffected skin is achieved through a selection of specific wavelengths at 1070, 1340 and 1605 nm and combining them in a pseudo‐red‐green‐blue color space. An image derived from these wavelengths normalized to unaffected skin defines a “tissue fluid index” that may aid in the quantitative diagnosis and monitoring of ACD. Further clinical testing of this promising approach towards disease detection and monitoring with tissue fluid content quantification is warranted.

中文翻译：

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短波红外过敏性接触性皮炎的高光谱成像和表征。

短波红外高光谱成像用于诊断和监测一例因接触毒藤而引起的过敏性接触性皮炎（ACD）病例。这种方法直接证明了 ACD 病变皮肤中组织液含量的增加，其光谱特征与皮内注射生理盐水的光谱特征相匹配。通过选择 1070、1340 和 1605 nm 的特定波长并将它们组合在伪红绿蓝色彩空间中，可以实现受影响和未受影响皮肤之间的最佳对比度。根据未受影响皮肤归一化的这些波长得出的图像定义了“组织液指数”，这可能有助于 ACD 的定量诊断和监测。有必要对这种通过组织液含量定量进行疾病检测和监测的有前途的方法进行进一步的临床测试。