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Suppressed immune profile in children with combined type 1 diabetes and celiac disease.
Clinical & Experimental Immunology ( IF 4.6 ) Pub Date : 2020-05-16 , DOI: 10.1111/cei.13454 A Tompa 1, 2 , K Åkesson 3 , S Karlsson 1 , M Faresjö 1
Clinical & Experimental Immunology ( IF 4.6 ) Pub Date : 2020-05-16 , DOI: 10.1111/cei.13454 A Tompa 1, 2 , K Åkesson 3 , S Karlsson 1 , M Faresjö 1
Affiliation
Children diagnosed with a combination of type 1 diabetes (T1D) and celiac disease (CD) show a dysregulated T helper type 1 (Th1)/Th17 response. Besides the cellular involvement, several soluble immune markers are involved in the autoimmune process of both T1D and CD. Only few studies have examined the peripheral pattern of different cytokines, chemokines and acute‐phase proteins (APP) in children with combined T1D and CD. To our knowledge, no studies have evaluated the serum levels of adipocytokines and matrix metalloproteinases (MMPs) in this context. The purpose of the present study was to acquire more knowledge and to gain deeper understanding regarding the peripheral immunoregulatory milieu in children with both T1D and CD. The study included children diagnosed with both T1D and CD (n = 18), children with T1D (n = 27) or CD (n = 16) and reference children (n = 42). Sera were collected and analysis of 28 immune markers (cytokines, chemokines, APPs, adipocytokines and MMPs) was performed using the Luminex technique. The major findings showed that children with a double diagnosis had lower serum levels of interleukin (IL)‐22, monocyte chemoattractant protein (MIP)‐1α, monocyte chemoattractant protein (MCP)‐1, procalcitonin, fibrinogen, visfatin and matrix metalloproteinase (MMP)‐2. These results indicate a suppressed immune profile in children with combined T1D and CD, including Th17 cytokines, chemokines, APPs, adipocytokines and MMPs. We conclude that, besides cytokines and chemokines, other immune markers, e.g. APPs, adipocytokines and MMPs, are of importance for further investigations to elucidate the heterogeneous immune processes present in patients diagnosed with T1D in combination with CD.
中文翻译:
合并1型糖尿病和腹腔疾病的儿童的免疫系统受到抑制。
被诊断患有1型糖尿病(T1D)和腹腔疾病(CD)合并症的儿童表现出1型T辅助者(Th1)/ Th17反应异常。除细胞参与外,T1D和CD的自身免疫过程还涉及多种可溶性免疫标记。只有很少的研究检查了合并T1D和CD的儿童中不同细胞因子,趋化因子和急性期蛋白(APP)的外周模式。据我们所知,在这种情况下,尚无研究评估血清脂肪细胞因子和基质金属蛋白酶(MMP)的水平。本研究的目的是获得更多的知识,并加深对T1D和CD患儿外周免疫调节环境的了解。该研究包括被诊断患有T1D和CD的儿童(n = 18),患有T1D(n = 27)或CD(n = 16)的儿童和参考儿童(n = 42)。收集血清,并使用Luminex技术分析28种免疫标记(细胞因子,趋化因子,APP,脂肪细胞因子和MMP)。主要发现表明,双重诊断的儿童血清白细胞介素(IL)-22,单核细胞趋化蛋白(MIP)-1α,单核细胞趋化蛋白(MCP)-1,降钙素,纤维蛋白原,visfatin和基质金属蛋白酶(MMP)的血清水平较低)‐2。这些结果表明,合并了T1D和CD的儿童(包括Th17细胞因子,趋化因子,APP,脂肪细胞因子和MMP)的免疫特征受到抑制。我们得出的结论是,除了细胞因子和趋化因子外,其他免疫标记物(例如APP,脂肪细胞因子和MMP)对于进一步研究以阐明诊断为CD的T1D患者存在的异质免疫过程也很重要。
更新日期:2020-05-16
中文翻译:
合并1型糖尿病和腹腔疾病的儿童的免疫系统受到抑制。
被诊断患有1型糖尿病(T1D)和腹腔疾病(CD)合并症的儿童表现出1型T辅助者(Th1)/ Th17反应异常。除细胞参与外,T1D和CD的自身免疫过程还涉及多种可溶性免疫标记。只有很少的研究检查了合并T1D和CD的儿童中不同细胞因子,趋化因子和急性期蛋白(APP)的外周模式。据我们所知,在这种情况下,尚无研究评估血清脂肪细胞因子和基质金属蛋白酶(MMP)的水平。本研究的目的是获得更多的知识,并加深对T1D和CD患儿外周免疫调节环境的了解。该研究包括被诊断患有T1D和CD的儿童(n = 18),患有T1D(n = 27)或CD(n = 16)的儿童和参考儿童(n = 42)。收集血清,并使用Luminex技术分析28种免疫标记(细胞因子,趋化因子,APP,脂肪细胞因子和MMP)。主要发现表明,双重诊断的儿童血清白细胞介素(IL)-22,单核细胞趋化蛋白(MIP)-1α,单核细胞趋化蛋白(MCP)-1,降钙素,纤维蛋白原,visfatin和基质金属蛋白酶(MMP)的血清水平较低)‐2。这些结果表明,合并了T1D和CD的儿童(包括Th17细胞因子,趋化因子,APP,脂肪细胞因子和MMP)的免疫特征受到抑制。我们得出的结论是,除了细胞因子和趋化因子外,其他免疫标记物(例如APP,脂肪细胞因子和MMP)对于进一步研究以阐明诊断为CD的T1D患者存在的异质免疫过程也很重要。