Nickel necrosis: Osteosarcoma is the most prevalent primary bone cancer amongst adults and children. A nickel(II) coordination complex containing one 1,10‐phenanthroline ligand and two N,N‐diethyldithiocarbamate moieties is shown to kill osteosarcoma cells by necroptosis, an ordered form of necrosis. Encouragingly, the nickel complex kills bulk osteosarcoma cells and hard‐to‐kill osteosarcoma stem cell (OSC) comparably at micromolar concentrations.

中文翻译：

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坏死病诱导的镍（II）-菲咯啉配合物的大块骨肉瘤和骨肉瘤干细胞活性。

镍坏死：骨肉瘤是成人和儿童中最普遍的原发性骨癌。包含一个1,10-菲咯啉配体和两个N，N-二乙基二硫代氨基甲酸酯部分的镍（II）配位复合物可通过坏死性坏死性杀伤骨肉瘤细胞而被杀死。令人鼓舞的是，在微摩尔浓度下，镍复合物可杀死大量的骨肉瘤细胞和难以杀死的骨肉瘤干细胞（OSC）。