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RNA Splicing and Cancer.
Trends in Cancer ( IF 18.4 ) Pub Date : 2020-05-17 , DOI: 10.1016/j.trecan.2020.04.011
Eric Wang 1 , Iannis Aifantis 1
Affiliation  

RNA splicing is an essential process that governs many aspects of cellular proliferation, survival, and differentiation. Considering the importance of RNA splicing in gene regulation, alterations in this pathway have been implicated in many human cancers. Large-scale genomic studies have uncovered a spectrum of splicing machinery mutations that contribute to tumorigenesis. Moreover, cancer cells are capable of hijacking the expression of RNA-binding proteins (RBPs), leading to dysfunctional gene splicing and tumor-specific dependencies. Advances in next-generation RNA sequencing have revealed tumor-specific isoforms associated with these alterations, including the presence of neoantigens, which serve as potential immunotherapeutic targets. In this review, we discuss the various mechanisms by which cancer cells exploit RNA splicing to promote tumor growth and the current therapeutic landscape for splicing-based therapies.



中文翻译:

RNA剪接与癌症。

RNA 剪接是控制细胞增殖、存活和分化的许多方面的重要过程。考虑到 RNA 剪接在基因调控中的重要性,该途径的改变与许多人类癌症有关。大规模基因组研究发现了一系列有助于肿瘤发生的剪接机制突变。此外,癌细胞能够劫持 RNA 结合蛋白 (RBP) 的表达,导致基因剪接功能障碍和肿瘤特异性依赖性。下一代 RNA 测序的进展揭示了与这些改变相关的肿瘤特异性亚型,包括作为潜在免疫治疗靶点的新抗原的存在。在这次审查中,

更新日期:2020-05-17
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