The constant exposure of ocular surface to external environment and then to several microbial agents is often related to the pathogenesis of various inflammatory eye disorders.

In the present study α-Smooth Muscle Actin (α-SMA) and Langerin CD/207 expression and function was investigated in a rabbit corneal keratitis. The inflammation was induced by the secreted form of glycoprotein B (gB1s) of HSV-1, in an ex vivo rabbit corneal model. α-SMA is often used as a marker for myofibroblasts. In this study, for the first time, we show α-SMA positive corneal epithelial cells, during HSV-1 cornea inflammation, demonstrating a crucial role in wound healing, especially during remodeling phase.

Furthermore, we show the presence of Dendritic Cells Langerin CD/207 positive, located mainly in the basal epithelial layer and in corneal stroma during the inflammatory processes. Our result validating the ex vivo organotypic rabbit corneal model, for the study about pathogenesis of HSV-1 ocular infection.

眼表不断暴露于外部环境，然后暴露于多种微生物制剂通常与各种炎症性眼病的发病机理有关。

在本研究中，在兔角膜角膜炎中研究了α-平滑肌肌动蛋白（α-SMA）和Langerin CD / 207的表达和功能。在离体兔角膜模型中，HSV-1的糖蛋白B（gB1s）的分泌形式诱发了炎症。α-SMA通常用作成肌纤维细胞的标志物。在这项研究中，我们首次展示了在HSV-1角膜炎症过程中，α-SMA阳性角膜上皮细胞在伤口愈合，尤其是在重塑阶段显示出至关重要的作用。

此外，我们显示出树突状细胞Langerin CD / 207阳性，在炎症过程中主要位于基底上皮层和角膜基质中。我们的结果验证了体外器官型兔角膜模型，用于研究HSV-1眼部感染的发病机理。