An increasing number of children are diagnosed with differentiated thyroid cancer. With an excellent prognosis for the majority of pediatric patients, the goal of therapy is to optimize outcome while reducing complications. Increased knowledge of the somatic, oncogenic driver mutations provides opportunities to improve the accuracy of diagnosis, to stratify surgery, and to treat patients with morbidly invasive or refractory disease. Treatment complications can be reduced by referral to regional, high-volume pediatric thyroid centers.

中文翻译：

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儿童和青少年的乳头状和滤泡状甲状腺癌：目前的方法和未来的方向。

越来越多的儿童被诊断出患有分化型甲状腺癌。由于大多数儿科患者的预后良好，因此治疗的目标是在减少并发症的同时优化结果。增加对体细胞、致癌驱动突变的了解提供了提高诊断准确性、手术分层和治疗病态侵袭性或难治性疾病患者的机会。通过转诊到区域性、高容量的儿科甲状腺中心，可以减少治疗并发症。