Pseudopeptidic poly(2-oxazoline)s are a special class of bio-inspired polymers with multiple applications, especially in the field of polymer therapeutics. Unsurprisingly, poly(2-oxazoline) has been extensively studied in recent decades, and pioneering studies on these polymers have shown that non-ionic, hydrophilic and thermo-responsive poly(2-oxazoline)s are comparable to and sometimes even more advantageous than poly(ethylene glycol) for biomedical applications. Considering their applications in the biomedical field, stimuli-responsive polymer materials open new opportunities for in vivo applications such as on-demand drug delivery, tissue repairing, biosensing and smart coatings, among others. In this context, this article is a comprehensive review of recent advances in stimuli-responsive polymers/interfaces consisting of poly(2-oxazoline)-based “smart” homopolymer and (co)polymer materials responsive to different single stimulus or to multiple stimuli. In particular, we focus on the synthesis (design strategies), “smart” solution properties (tuning of cloud points), self-assembly (tuning of nanostructures), surface chemistry (surface grafting strategies, antifouling properties, responsive behaviors) and possible biomedical applications of different stimulus-responsive materials based on functionalized poly(2-oxazoline). Accordingly, this review can be used as a benchmark for biopolymer researchers, thereby helping them design innovative functional poly(2-oxazoline)-based “smart” bio-inspired materials for novel applications by highlighting key research gaps and future research avenues in this dynamic and highly relevant field of research.

伪肽聚（2-恶唑啉）是一类特殊的生物启发型聚合物，具有多种应用，尤其是在聚合物治疗领域。毫无疑问，近几十年来对聚（2-恶唑啉）进行了广泛的研究，对这些聚合物的开创性研究表明，非离子型，亲水性和热响应性的聚（2-恶唑啉）具有可比性，有时甚至比用于生物医学的聚乙二醇。考虑到它们在生物医学领域的应用，刺激响应性高分子材料为体内打开了新的机会应用，例如按需给药，组织修复，生物传感和智能涂层等。在这种情况下，本文是对刺激响应性聚合物/界面的最新进展的全面综述，该聚合物/界面由基于聚（2-恶唑啉）的“智能”均聚物和对不同刺激或多种刺激响应的（共）聚合物材料组成。特别是，我们专注于合成（设计策略），“智能”解决方案特性（浊点的调整），自组装（纳米结构的调整），表面化学（表面接枝策略，防污性能，响应行为）和可能的生物医学功能化聚（2-恶唑啉）的不同刺激响应材料的应用 因此，该评论可作为生物聚合物研究人员的基准，