Guillain-Barré syndrome (GBS) is an immune-mediated neurological disorder with a multifaceted nature. Infectious agents and immune-response genetic host factors may contribute to the development of GBS. The matrix metalloproteinase-9 (MMP-9), an enzyme is upregulated by pro-inflammatory cytokines and might play an important role in the pathogenesis of GBS. This study investigated the association of a single nucleotide polymorphism (-1562C/T, rs3918242) in the MMP9 gene with the susceptibility and severity of GBS in Bangladesh. The allele and genotype distributions of the MMP9 polymorphism were not significantly different between 303 patients with GBS and 303 healthy controls. Serum concentrations of MMP-9 were significantly elevated in patients with GBS compared to healthy controls (P ≤.0001). No significant association of MMP-9 (-1562C/T) polymorphism was observed with disease prognosis. The frequencies of the MMP9-1562 CT genotype and T allele (P = .01, OR = 2.28, 95% CI = 1.22-4.22; Pc = 0.03 and P = .012, OR = 2.0, 95% CI = 1.14-3.38; Pc = 0.024, respectively) were significantly increased in patients with severe form of GBS, indicates the MMP9 polymorphism plays a role in the disease severity of GBS.

中文翻译：

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基质金属蛋白酶9多态性与格林-巴利综合征严重程度的关联

格林-巴利综合征 (GBS) 是一种免疫介导的神经系统疾病，具有多方面的性质。传染性病原体和免疫反应遗传宿主因素可能有助于 GBS 的发展。基质金属蛋白酶 9 (MMP-9) 是一种被促炎细胞因子上调的酶，可能在 GBS 的发病机制中起重要作用。本研究调查了 MMP9 基因中的单核苷酸多态性 (-1562C/T, rs3918242) 与孟加拉国 GBS 易感性和严重性的关联。MMP9 多态性的等位基因和基因型分布在 303 名 GBS 患者和 303 名健康对照之间没有显着差异。与健康对照组相比，GBS 患者的血清 MMP-9 浓度显着升高（P ≤.0001）。未观察到 MMP-9 (-1562C/T) 多态性与疾病预后显着相关。MMP9-1562 CT 基因型和 T 等位基因的频率 (P = .01, OR = 2.28, 95% CI = 1.22-4.22; Pc = 0.03 and P = .012, OR = 2.0, 95% CI = 1.14-3.38 ; Pc = 0.024，分别）在严重型GBS患者中显着增加，表明MMP9多态性在GBS的疾病严重程度中起作用。