Aims

Devices and modalities applied for transcatheter strategy for atrial septal defect (ASD) closure have been evolved leading high successfulness with minimal complications and thus this modality has been accepted as the choice for repairing ASD in adults as compared to invasive surgical procedures. We performed a systematic review and meta-analysis of published studies to characterize the current literature and help determine the long-term outcomes after transcatheter ASD closure in adults.

Methods and Results

Two investigators searched the manuscript databases for all eligible studies in accordance with the considered keywords. Of total 118 studies, 14 met the endpoints that were finally analyzed that were published between 2010 and 2019.

Fourteen studies assessed the outcomes after transcatheter ASD closure in adults within a follow-up time ranged 3 to 9 years. The total number of patients was 2354. The pooled prevalence of each event according to the meta-analysis and considering the weight calculated for each study included 10.1% (for arrhythmia), 1.8% (for emboli), 2.3% (for stroke), 12.5% (for residual shunt), 1.8% (for erosion), and 2.5% (for death).

Conclusion

The present meta-analysis show high long-term successfulness of transcatheter ASD closure in adults, however high rate of some events such as residual shunting and cardiac arrhythmia emphasizes further examination of the techniques used, the criteria for selecting patients, and the use of better devices for practice.

Condensed Abstract:

Aims: We performed a systematic review and meta-analysis of published studies to characterize the current literature and help determine the long-term outcomes after transcatheter ASD closure in adults.

Methods and Results: Two investigators searched the manuscript databases for all eligible studies in accordance with the considered keywords. The pooled prevalence of each event according to the meta-analysis and considering the weight calculated for each study included 10.1% (for arrhythmia), 1.8% (for emboli), 2.3% (for stroke), 12.5% (for residual shunt), 1.8% (for erosion), and 2.5% (for death).

Conclusion:The present meta-analysis show high long-term successfulness of transcatheter ASD closure in adults

中文翻译：

---

成人经导管房间隔缺损闭合后的长期结果：系统评价和荟萃分析。

目的

用于房间隔缺损（ASD）闭合的经导管策略的设备和方式已得到发展，具有极高的成功率和最小的并发症，因此，与侵入性外科手术相比，该方式已被视为修复成人ASD的选择。我们对发表的研究进行了系统的回顾和荟萃分析，以表征当前文献并帮助确定成人经导管ASD封堵后的长期预后。

方法与结果

两名研究人员根据所考虑的关键字，在手稿数据库中搜索了所有符合条件的研究。在总共118项研究中，有14项达到了最终分析的终点，这些终点于2010年至2019年之间发表。

十四项研究评估了成人经导管ASD关闭后的随访结果，随访时间为3至9年。患者总数为2354。根据荟萃分析，考虑到每个研究计算得出的体重，每个事件的合并患病率包括10.1％（心律失常），1.8％（栓塞），2.3％（中风）， 12.5％（用于残余分流），1.8％（用于腐蚀）和2.5％（用于死亡）。

结论

当前的荟萃分析显示成人经导管ASD封闭的长期成功率很高，但是某些事件的高发生率，例如残余分流和心律不齐，强调了进一步检查所用技术，选择患者标准以及使用更好的方法的可能性。练习设备。

浓缩摘要：

目的：我们对发表的研究进行了系统的回顾和荟萃分析，以表征当前文献并帮助确定成人经导管ASD封堵后的长期结局。

方法和结果：两名研究者根据所考虑的关键词在手稿数据库中搜索了所有符合条件的研究。根据荟萃分析汇总每个事件的患病率，并考虑为每个研究计算的权重，包括10.1％（心律失常），1.8％（栓塞），2.3％（中风），12.5％（残余分流）， 1.8％（用于侵蚀）和2.5％（用于死亡）。

结论：本荟萃分析显示成人经导管ASD封闭的长期成功性