In order to accelerate development of atherosclerosis(AS) in miniature swine models, varieties of strategies and methods have been explored. In addition to traditional methods such as high cholesterol feeding and balloon injury, new methods such as familial hypercholesterolemia induced by gene editing and intramural injection have been applied in recent years. Although it has been claimed that these methods have successfully aggravated lesion areas and stenosis, lesion features induced by different strategies have shown heterogeneity in morphology. In addition, time consumption, high cost, and unavailability are problems that restrict application of these AS models. Here, we summarize strategies and methods to accelerate AS models and further analyze their values, advantages, and shortcomings.

为了加速微型猪模型中动脉粥样硬化（AS）的发展，已经探索了各种策略和方法。除了传统的方法，例如高胆固醇喂养和球囊损伤外，近年来还应用了新方法，例如通过基因编辑和壁内注射诱导的家族性高胆固醇血症。尽管已经声称这些方法已经成功地加重了病变区域和狭窄，但是通过不同策略诱导的病变特征在形态上显示出异质性。另外，时间消耗，高成本和不可用性是限制这些AS模型的应用的问题。在这里，我们总结了加速AS模型的策略和方法，并进一步分析了它们的价值，优势和不足。