SLC26A3 (DRA) mediates the absorption of luminal Cl⁻ in exchange for HCO₃⁻ in the distal intestine. Its expression is lost in congenital chloride diarrhoea (CLD) and strongly decreased in the presence of intestinal inflammation. To characterize the consequences of a loss of Slc26a3 beyond disturbed electrolyte transport, colonic mucus synthesis, surface accumulation and composition, pH microclimate, microbiome composition and development of inflammation was studied in slc26a3^−/− mice.

中文翻译：

---

Slc26a3 缺失会改变 pH 微气候、粘蛋白生物合成、微生物组组成并增加小鼠结肠中 TNFα 的表达。

SLC26A3 (DRA) 介导 luminal Cl ^-的吸收，以交换远端肠道中的 HCO ₃ ^-。其表达在先天性氯化物腹泻 (CLD) 中丢失，并且在肠道炎症存在时强烈降低。为了表征 Slc26a3 丧失超出电解质转运受干扰的后果，在slc26a3 ^-/-小鼠中研究了结肠粘液合成、表面积累和组成、pH 微气候、微生物组组成和炎症发展。