AIMS Vitamin D measurement is a composite of vitamin D2 (25(OH)D2) and D3 (25(OH)D3) levels, and its deficiency is associated with the development of type 2 diabetes (T2DM) and diabetic complications; vitamin D deficiency may be treated with vitamin D2 supplements. This study was undertaken to determine if vitamin D2 and D3 levels differed between those with and without T2DM in this Middle Eastern population, and the relationship between diabetic microvascular complications and vitamin D2 and vitamin D3 levels in subjects with T2DM. METHODS: Four hundred ninety-six Qatari subjects, 274 with and 222 without T2DM participated in the study. Plasma levels of total vitamin D2 and D3 were measured by LC-MS/MS analysis. RESULTS All subjects were taking vitamin D2 and none were taking D3 supplements. Vitamin D2 levels were higher in diabetics, particularly in females, and higher levels were associated with hypertension and dyslipidemia in the diabetic subjects (p < 0.001), but were not related to diabetic retinopathy or nephropathy. Vitamin D3 levels measured in the same subjects were lower in diabetics, particularly in females (p < 0.001), were unrelated to dyslipidemia or hypertension, but were associated with retinopathy (p < 0.014). Neither vitamin D2 nor vitamin D3 were associated with neuropathy. For those subjects with hypertension, dyslipidemia, retinopathy or neuropathy, comparison of highest with lowest tertiles for vitamin D2 and vitamin D3 showed no difference. CONCLUSIONS In this Qatari cohort, vitamin D2 was associated with hypertension and dyslipidemia, whilst vitamin D3 levels were associated with diabetic retinopathy. Vitamin D2 levels were higher, whilst vitamin D3 were lower in diabetics and females, likely due to ingestion of vitamin D2 supplements.

中文翻译：

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维生素D2和D3与2型糖尿病并发症的关联。

AIMS维生素D测量是维生素D2（25（OH）D2）和D3（25（OH）D3）水平的综合，其缺乏与2型糖尿病（T2DM）的发展和糖尿病并发症有关；维生素D缺乏症可以用维生素D2补充剂治疗。进行这项研究是为了确定中东人群中有和没有T2DM的人群中维生素D2和D3水平是否存在差异，以及糖尿病微血管并发症与T2DM受试者中维生素D2和维生素D3水平之间的关系。方法：496名卡塔尔受试者，274名有T2DM的受试者和222名无T2DM的受试者参加了该研究。通过LC-MS / MS分析测量血浆中总维生素D2和D3的水平。结果所有受试者均服用维生素D2，均未服用D3补充剂。糖尿病患者的维生素D2水平较高，特别是在女性中，糖尿病患者中较高的水平与高血压和血脂异常有关（p <0.001），但与糖尿病性视网膜病变或肾病无关。在同一受试者中测得的维生素D3水平在糖尿病患者中较低，尤其是在女性中（p <0.001），与血脂异常或高血压无关，但与视网膜病变相关（p <0.014）。维生素D2和维生素D3均与神经病变无关。对于患有高血压，血脂异常，视网膜病变或神经病的受试者，比较维生素D2和维生素D3的最高和最低三分位数无差异。结论在这个卡塔尔队列中，维生素D 2与高血压和血脂异常有关，而维生素D 3水平与糖尿病性视网膜病有关。维生素D2含量较高，