Objectives To determine the association of pre- and postinterventional serum levels of interleukin-6 and high-sensitivity C-reactive protein at the six-month evaluation of restenosis after stenting of the femoropopliteal artery. Methods Sixty-eight consecutive patients with steno-occlusive femoropopliteal artery disease of Rutherford category III or IV who underwent stent implantation were included. Six-month patency was evaluated with color-coded duplex ultrasound. The association of in-stent restenosis with interleukin-6 and high-sensitivity C-reactive protein levels at baseline, and 24-h postintervention was assessed with a multivariate logistic regression analysis. Results In-stent restenosis was found in 15 patients (22.1%) within six months. Interleukin-6 and high-sensitivity C-reactive protein levels were significantly increased at 24-h postintervention compared to their preintervention values (p < 0.001 and p = 0.002, respectively). Interleukin-6 values at baseline (odds ratio, 1.11; 95% confidence interval: 1.00, 1.23; p = 0.044) and 24-h postintervention (odds ratio, 1.04; 95% confidence interval: 1.02, 1.06; p < 0.001) were independently associated with six-month in-stent restenosis. Twenty-four-hour postinterventional high-sensitivity C-reactive protein levels were also found to be related to restenosis (odds ratio, 1.15; 95% confidence interval: 1.04, 1.26; p = 0.006), but high-sensitivity C-reactive protein levels at baseline did not show an independent association with in-stent restenosis (odds ratio, 0.57; 95% confidence interval: 0.35, 1.80; p = 0.667). Smoking, diabetes mellitus, and cumulative stent length were other parameters associated with an increased risk for in-stent restenosis. Conclusions Femoropopliteal artery angioplasty with stent placement induces an inflammatory response. Interleukin-6 is a powerful independent predictor of intermediate-term outcomes for stenting of the femoropopliteal artery, suggesting that its predictive value may be superior to that of high-sensitivity C-reactive protein.

中文翻译：

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股腘动脉支架置入术6个月结果及白细胞介素6的预测价值：与高敏C反应蛋白的比较

目的 在股腘动脉支架置入术后 6 个月的再狭窄评估中，确定介入前和介入后血清 IL-6 和高敏 C 反应蛋白水平的相关性。方法 连续纳入 68 例接受支架植入术的 Rutherford III 或 IV 级狭窄闭塞性股腘动脉疾病患者。使用彩色编码的双工超声评估 6 个月的通畅率。支架内再狭窄与基线和干预后 24 小时的白细胞介素 6 和高敏 C 反应蛋白水平的关联通过多变量逻辑回归分析进行评估。结果 6个月内发现支架内再狭窄15例（22.1%）。与干预前值相比，白细胞介素 6 和高敏 C 反应蛋白水平在干预后 24 小时显着增加（分别为 p < 0.001 和 p = 0.002）。基线（比值比，1.11；95% 置信区间：1.00，1.23；p = 0.044）和干预后 24 小时（比值比，1.04；95% 置信区间：1.02，1.06；p < 0.001）的白细胞介素 6 值与 6 个月支架内再狭窄独立相关。还发现介入后 24 小时高敏 C 反应蛋白水平与再狭窄有关（优势比，1.15；95% 置信区间：1.04, 1.26；p = 0.006），但高敏 C 反应蛋白水平基线水平未显示与支架内再狭窄的独立关联（优势比，0.57；95% 置信区间：0.35, 1.80；p = 0.667）。抽烟，糖尿病和累积支架长度是与支架内再狭窄风险增加相关的其他参数。结论 支架置入股腘动脉血管成形术诱导炎症反应。白细胞介素 6 是股腘动脉支架置入术中期结果的强有力的独立预测因子，表明其预测价值可能优于高敏 C 反应蛋白。