The PIDDosome is a multiprotein complex that drives activation of caspase-2, an endopeptidase originally implicated in apoptosis. Yet, unlike other caspases involved in cell death and inflammation, caspase-2 seems to exert additional versatile functions unrelated to cell death. These emerging roles range from control of transcription factor activity to ploidy surveillance. Thus, caspase-2 and the PIDDosome act as a critical regulatory unit controlling cellular differentiation processes during organogenesis and regeneration. These newly established functions of the PIDDosome and its downstream effector render its components attractive targets for drug-development aiming to prevent fatty liver diseases, neurodegenerative disorders or osteoporosis.

中文翻译：

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揭示 PIDDosome 和 caspase-2 作为器官发生和细胞分化的调节剂。

PIDDosome 是一种多蛋白复合物，可驱动 caspase-2（一种最初与细胞凋亡有关的内肽酶）的激活。然而，与参与细胞死亡和炎症的其他 caspase 不同，caspase-2 似乎发挥了与细胞死亡无关的其他多功能功能。这些新出现的作用范围从转录因子活性的控制到倍性监视。因此，caspase-2 和 PIDDosome 在器官发生和再生过程中充当控制细胞分化过程的关键调节单元。PIDDosome 及其下游效应器的这些新建立的功能使其组件成为旨在预防脂肪肝疾病、神经退行性疾病或骨质疏松症的药物开发的有吸引力的目标。