Virus cause multiple outbreaks, for which comprehensive tailored therapeutic strategies are still missing. Virus and host cell dynamics are strictly connected, and convey in virion assembly to ensure virus spread in the body. Study of the systemic behavior of virus-host interaction at the single-cell level is a scientific challenge, considering the difficulties of using experimental approaches and the limited knowledge of the behavior of emerging novel virus as a collectivity. This work focuses on positive-sense, single-stranded RNA viruses, like human coronaviruses, in their virus individual host interaction, studying the changes induced in the host cell bioenergetics. A systems-thinking representation, based on stock-flow diagramming of virus-host interaction at the cellular level, is used here for the first time to simulate the system energy dynamics. We found that reducing the energy flow which fuels virion assembly is the most affordable strategy to limit the virus spread, but its efficacy is mitigated by the contemporary inhibition of other flows relevant for the system.

中文翻译：

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病毒-宿​​主协同进化系统配置的能量动力学

病毒引起多种疾病爆发，为此仍缺乏针对性的综合治疗策略。病毒和宿主细胞动力学是紧密相连的，并以病毒体组装形式传播，以确保病毒在体内传播。考虑到使用实验方法的困难以及对新兴新型病毒作为集合体的行为的了解有限，在单细胞水平上研究病毒-宿主相互作用的系统行为是一项科学挑战。这项工作侧重于正向，单链RNA病毒（如人冠状病毒）在其病毒个体宿主相互作用中的作用，研究了宿主细胞生物能学中诱导的变化。基于系统思想的表示形式，基于细胞水平上病毒-宿主相互作用的库存流图，首次在此处用于模拟系统能量动力学。我们发现，减少病毒粒子组装所需的能量流是限制病毒传播的最经济的策略，但是由于当代抑制了与该系统相关的其他能量流，其有效性降低了。