Chronic spontaneous urticaria (CSU) is considered an autoimmune disorder in 50% of cases at least, in which T‐ and mast cell mediators are considered to be the primary cause of symptoms. However, H1‐antihistamines, cyclosporine A, and omalizumab fail to achieve complete symptom amelioration in up to 70% of patients. This suggests that other inflammatory pathways are involved and that additional and more effective treatments need to be developed.

中文翻译：

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白细胞介素 17 是严重慢性自发性荨麻疹的潜在参与者和治疗目标

至少在 50% 的病例中，慢性自发性荨麻疹 (CSU) 被认为是一种自身免疫性疾病，其中 T 细胞和肥大细胞介质被认为是导致症状的主要原因。然而，H1-抗组胺药、环孢素 A 和奥马珠单抗未能在多达 70% 的患者中实现完全的症状改善。这表明还涉及其他炎症通路，需要开发其他更有效的治疗方法。