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Blood markers of osteoclastic differentiation in periparturient dairy cows at different parities, with and without milk fever.
Research in Veterinary Science ( IF 2.4 ) Pub Date : 2020-05-15 , DOI: 10.1016/j.rvsc.2020.05.009
Kaoru Hatate 1 , Chiho Kawashima 2 , Mitsunori Kayano 3 , Masaaki Hanada 4 , Norio Yamagishi 1
Affiliation  

Osteoprotegerin (OPG) inhibits osteoclast (OC) differentiation. TRAP5b (tartrate-resistant acid phosphatase 5b) secreted by OCs reflects the numbers of mature OCs. This study assessed these OC-related markers around parturition in cows of different parities and in cows with milk fever (MF). The blood OPG and TRAP5b concentrations, as well as the ratio of OPG to TRAP5b (O/T), were measured beginning 3 weeks before (-21 d) and over a few days after calving in 49 Holstein Friesian cows at first (n = 8), second (n = 17), third (n = 12), and fourth or greater (n = 12) parities. The ratio of O/T at -21 d to O/T at calving (PreCOT) was also calculated. In the third and greater parities, seven cows developed MF (non-MF, n = 17). Regardless of the development of MF, the serum OPG started to decline in the last week of gestation only in the cows entering the second lactation, while the blood TRAP5b increased at calving in all cows. O/T decreased toward parturition only in multiparous cows. The decrease in O/T at caving was less pronounced in MF cows. PreCOT was negatively correlated with lactation number only in multiparous cows (n = 41, ρ = -0.50, P < .01). This study implied that OC differentiation toward calving was tapered in cows with advanced parities, and these indexes predict the risk of MF.

中文翻译:

有和没有发烧的不同胎次围产期奶牛破骨细胞分化的血液标志物。

骨保护素(OPG)抑制破骨细胞(OC)分化。OC分泌的TRAP5b(抗酒石酸酸性磷酸酶5b)反映了成熟OC的数量。这项研究评估了不同胎次的奶牛和有乳热(MF)的牛在分娩前后这些与OC有关的标志物。首先在49头荷斯坦黑白花奶牛产犊前三周(-21天)和几天后测量血液中OPG和TRAP5b的浓度,以及OPG与TRAP5b的比率(O / T)。 8),第二(n = 17),第三(n = 12)和第四或更大(n = 12)奇偶校验。还计算了-21 d时O / T与产犊时O / T的比率(PreCOT)。在第三胎和更高胎胎中,有七头母牛出现了中频(非中频,n = 17)。不管MF的发展如何,仅在进入第二次泌乳的母牛在妊娠的最后一周血清OPG开始下降,而所有母牛的产犊时血液TRAP5b均升高。O / T仅在多头母牛中朝着分娩下降。MF母牛探空时O / T的下降不太明显。仅在多头母牛中,PreCOT与泌乳次数呈负相关(n = 41,ρ= -0.50,P <.01)。这项研究表明,在高等胎的母牛中,OC向产犊的分化逐渐减小,这些指标预测了发生MF的风险。
更新日期:2020-05-15
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