BACKGROUND AND PURPOSE The increased prevalence of cancer has led to it being considered an important factor in the cause of cryptogenic stroke. In recent years, polyunsaturated fatty acids, particularly omega-3 polyunsaturated fatty acids, have been shown to prevent cancer development and progression. This study aimed to clarify the characteristics of serum polyunsaturated fatty acids in cryptogenic stroke with active cancer. METHODS The serum levels polyunsaturated fatty acid fractions (eicosapentaenoic acid, EPA; docosahexaenoic acid, DHA; dihomo-gamma-linolenic acid, DHLA; and arachidonic acid, AA) in cases of cryptogenic stroke, sampled within 5 days after admission, were measured. Active cancer was defined as a new diagnosis, treatment, progression or recurrence within 6 months before admission, or metastatic cancer. Multivariate logistic regression analyses were performed to explore the relationship between serum polyunsaturated fatty acids and cryptogenic stroke with active cancer. RESULTS Among 123 cases classified as cryptogenic stroke, 27 had active cancer. The serum EPA levels (1.26 ± 0.72 versus 1.89 ± 1.27 umol/l; P = 0.02) were significantly lower in cryptogenic stroke with active cancer, whereas the serum DHA, DHLA and AA levels did not significantly differ. Multivariate logistic analysis revealed that the serum EPA levels were associated with cryptogenic stroke with active cancer independently of age and serum D-dimer levels (odds ratio, 0.974; 95% confidence interval, 0.949-0.999; P = 0.04). CONCLUSIONS In our study, low serum EPA levels were associated with cryptogenic stroke with active cancer. This suggests that low serum EPA levels may have some involvement in the pathogenesis of cryptogenic stroke with active cancer.

中文翻译：

---

患有活动性癌症的隐源性卒中中的低血清二十碳五烯酸水平。

背景和目的癌症患病率的增加已导致其被认为是导致隐源性中风的重要因素。近年来，多不饱和脂肪酸，特别是omega-3多不饱和脂肪酸已被证明可以预防癌症的发展和发展。这项研究旨在阐明活动性癌症的隐源性卒中中血清多不饱和脂肪酸的特征。方法在入院后5天内对隐源性卒中患者的血清多不饱和脂肪酸级分（二十碳五烯酸，EPA，二十二碳六烯酸，DHA，二高-γ-亚麻酸，DHLA和花生四烯酸，AA）进行测量。活动性癌症定义为入院前6个月内的新诊断，治疗，进展或复发或转移性癌症。进行多变量logistic回归分析以探讨血清多不饱和脂肪酸与活动性癌症的隐源性中风之间的关系。结果在分类为隐源性中风的123例病例中，有27例患有活动性癌症。在患有活动性癌症的隐源性卒中中，血清EPA水平（1.26±0.72对1.89±1.27 umol / l； P = 0.02）显着降低，而血清DHA，DHLA和AA水平没有显着差异。多元逻辑分析表明，血清EPA水平与患有活动性癌症的隐源性卒中相关，与年龄和血清D-二聚体水平无关（比值比为0.974； 95％置信区间为0.949-0.999； P = 0.04）。结论在我们的研究中，低血清EPA水平与活动性癌症的隐源性中风有关。