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Filament formation by metabolic enzymes-A new twist on regulation.
Current Opinion in Cell Biology ( IF 7.5 ) Pub Date : 2020-05-14 , DOI: 10.1016/j.ceb.2020.04.006
Eric M Lynch 1 , Justin M Kollman 1 , Bradley A Webb 2
Affiliation  

Compartmentalization of metabolic enzymes through protein-protein interactions is an emerging mechanism for localizing and regulating metabolic activity. Self-assembly into linear filaments is a common strategy for cellular compartmentalization of enzymes. Polymerization is often driven by changes in the metabolic state of the cell, suggesting that it is a strategy for shifting metabolic flux in response to cellular demand. Although polymerization of metabolic enzymes is widespread, observed from bacteria to humans, we are just beginning to appreciate their role in regulating cellular metabolism. In most cases, one functional role of metabolic enzyme filaments is allosteric control of enzyme activity. Here, we highlight recent findings, providing insight into the structural and functional significance of filamentation of metabolic enzymes in cells.

中文翻译:

代谢酶的细丝形成——调控的新转折。

通过蛋白质-蛋白质相互作用对代谢酶进行区室化是定位和调节代谢活动的新兴机制。自组装成线性细丝是酶细胞区室化的常见策略。聚合通常由细胞代谢状态的变化驱动,这表明它是一种根据细胞需求改变代谢通量的策略。尽管从细菌到人类观察到代谢酶的聚合很普遍,但我们才刚刚开始意识到它们在调节细胞代谢中的作用。在大多数情况下,代谢酶丝的一种功能作用是酶活性的变构控制。在这里,我们强调了最近的发现,提供了对细胞中代谢酶丝状结构的结构和功能意义的深入了解。
更新日期:2020-05-14
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