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Current challenges and future trends in manufacturing small diameter artificial vascular grafts in bioreactors.
Cell and Tissue Banking ( IF 1.5 ) Pub Date : 2020-05-15 , DOI: 10.1007/s10561-020-09837-0
Farid Jafarihaghighi 1 , Mehdi Ardjmand 1 , Abolfazl Mirzadeh 2 , Mohammad Salar Hassani 1 , Shahriar Salemi Parizi 1, 3
Affiliation  

Cardiovascular diseases are a leading cause of death. Vascular surgery is mainly used to solve this problem. However, the generation of a functional and suitable substitute for small diameter (< 6 mm) displacement is challengeable. Moreover, synthetic prostheses, made of polyethylene terephthalate and extended polytetrafluoroethylene show have shown insufficient performance. Therefore, the challenges dominating the use of autografts have prevented their efficient use. Tissue engineering is highlighted in regenerative medicine perhaps in aiming to address the issue of end-stage organ failure. While organs and complex tissues require the vascular supply to support the graft survival and render the bioartificial organ role, vascular tissue engineering has shown to be a hopeful method for cell implantation by the production of tissues in vitro. Bioreactors are a salient point in vascular tissue engineering due to the capability for reproducible and controlled variations showing a new horizon in blood vessel substitution. This review strives to display the overview of current concepts in the development of small-diameter by using bioreactors. In this work, we show a critical look at different factors for developing small-diameter and give suggestions for future studies.

中文翻译:

在生物反应器中制造小直径人造血管移植物的当前挑战和未来趋势。

心血管疾病是死亡的主要原因。血管外科手术主要用于解决这个问题。但是,为小直径(<6 mm)位移的功能性和合适的替代物的产生带来挑战。此外,由聚对苯二甲酸乙二醇酯和扩展的聚四氟乙烯制成的合成假体显示出不足的性能。因此,控制自体移植的挑战阻碍了它们的有效使用。组织工程在再生医学中得到了强调,也许旨在解决晚期器官衰竭的问题。尽管器官和复杂组织需要血管供应来支持移植物存活并发挥生物人工器官的作用,但血管组织工程学已被证明是通过体外生产组织进行细胞植入的一种有希望的方法。生物反应器是血管组织工程学中的一个显着点,因为它具有可再现和受控变化的能力,显示了血管替代的新视野。这篇综述试图通过使用生物反应器来展示小直径开发中当前概念的概述。在这项工作中,我们对发展小直径的不同因素进行了批判性研究,并为以后的研究提供了建议。
更新日期:2020-05-15
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