The efficacy of pharmacological disruption of fear memory reconsolidation depends on several factors, including memory strength and age. We built on previous observations that systemic treatment with the nootropic nefiracetam potentiates cued fear memory destabilization to facilitate mifepristone-induced reconsolidation impairment. Here, we applied nefiratecam and mifepristone to strongly-conditioned, 1-week old contextual fear memories in male rats. Unexpectedly, the combined treatment did not result in impairment of contextual fear expression. However, mifepristone did reduce freezing to a novel context. These observations suggest that strong and established contextual fear memories do undergo destabilization without the need for pharmacological facilitation, and that impairments in strong context fear memory reconsolidation can manifest as a reduction in generalization.

中文翻译：

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激活后的米非司酮会削弱强条件情景恐惧记忆的泛化

恐惧记忆再巩固的药理学破坏功效取决于几个因素，包括记忆强度和年龄。我们基于先前的观察结果，以促智奈非西坦进行全身治疗可增强提示的恐惧记忆失稳，从而促进米非司酮引起的巩固障碍。在这里，我们将nefiratecam和米非司酮应用到雄性大鼠中条件强烈的1周龄上下文恐惧记忆中。出乎意料的是，联合治疗并未导致上下文恐惧表达受损。但是，米非司酮的确将冷冻作用降低到了新的境界。这些观察结果表明，强大而建立的情境恐惧记忆确实会不稳定，不需要药理作用，