Anosognosia in Alzheimer's disease (AD) is defined as a lack of awareness for cognitive deficits or severity of disease. Previous studies have highlighted the link between anosognosia and damage to prefrontal functioning, i.e., executive functions. This study investigated the neuropsychological and neurostructural substrates of domain specific anosognosia in early AD.

Fifty-three patients with a clinical diagnosis of early-AD and a reliable informant were administered the Measurement of Anosognosia Instrument, a validated tool to quantify anosognosia. Linear models were devised to test the association between the patient-informant discrepancy scores in the memory and non-memory domains and clinical profiles inclusive of cognitive scores and maps of grey matter.

Total anosognosia scores were associated with episodic memory, semantic memory, visuoconstructive skills and volume of the anterior cingulate cortex (ACC), lingual gyrus, fusiform gyrus and thalamus. Memory anosognosia was associated with episodic memory and visuoconstructive skills. Non-memory anosognosia was associated with episodic and semantic memory and with volume of the ACC, precentral gyrus, superior frontal gyrus, postcentral gyrus, fusiform gyrus and lingual gyrus.

Known as a region responsible for self-regulation and monitoring, reduction of grey matter in the frontal lobe was highlighted as crucial for the presence of anosognosia. Based on our findings, we argue that specific regions based in the frontal lobe could contribute to the functioning of the mnemonic comparator systems postulated by theoretical models of anosognosia. The cross-domain variability of cognitive correlates indicates that various computational mechanisms are at play in the presence of anosognosia.

阿尔茨海默氏病（AD）的厌食症定义为缺乏对认知缺陷或疾病严重程度的认识。先前的研究强调了失语症与前额叶功能（即执行功能）损害之间的联系。这项研究调查了早期AD特定领域的失语症的神经心理和神经结构底物。

对53例临床诊断为AD早期且可靠的线人患者进行了Anosognosia Instrument的测量，这是一种经过验证的量化鼻窦异位的工具。设计了线性模型，以测试记忆和非记忆域中的患者信息差异评分与临床资料（包括认知评分和灰质图）之间的关联。

总的失语症评分与情节记忆，语义记忆，视觉构造能力和前扣带回皮层（ACC），舌状回，梭状回和丘脑的体积有关。记忆的失语与发作性记忆和视觉建设技能有关。非记忆错觉与情节和语义记忆以及ACC，中央前回，上额额回，中央后回，梭状回和舌状回的体积有关。

额叶灰质的减少被认为是负责自我调节和监测的区域，对于存在失音症至关重要。根据我们的发现，我们认为基于额叶的特定模型区域可能会有助于失语症理论模型所假定的记忆比较系统的功能。认知相关因素的跨域变异性表明，在负听诊的情况下，各种计算机制都在起作用。