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The role of the aqueous extract Polypodium leucotomos in photoprotection.
Photochemical & Photobiological Sciences ( IF 3.1 ) Pub Date : 2020-05-14 , DOI: 10.1039/d0pp00124d
Concepción Parrado 1 , Jimena Nicolas 2 , Angeles Juarranz 2 , Salvador Gonzalez 3
Affiliation  

Solar radiation in the ultraviolet (UV), visible (VIS), and infrared (IR) ranges produces different biological effects in humans. Most of these, particularly those derived from ultraviolet radiation (UVR) are harmful to the skin, and include cutaneous aging and increased risk of cutaneous diseases, particularly skin cancer. Pharmacological photoprotection is mostly topical, but it can also be systemic. Oral photoprotectives constitute a new generation of drugs to combat the deleterious effects of solar radiation. Among these, an extract of Polypodium leucotomos (PL/Fernblock®, IFC Group, Spain) contains a high content of phenolic compounds that endow it with antioxidant activity. PL can administered orally or topically and is completely safe. PL complements and enhances endogenous antioxidant systems by neutralizing superoxide anions, hydroxyl radicals, and lipoperoxides. In addition to its antioxidant activity, PL also improves DNA repair and modulates immune and inflammatory responses. These activities are likely due to its ability to inhibit the generation and release of reactive oxygen species (ROS) by UVR, VIS, and IR radiation. PL also prevents direct DNA damage by accelerating the removal of induced photoproducts and decreasing UV-induced mutations. Oral PL increases the expression of active p53, decreases cell proliferation, and inhibits UV-induced COX-2 enzyme levels. PL has been used to treat skin diseases such as photodermatoses and pigmentary disorders and recently as a complement of photodynamic phototherapy in actinic keratoses. The photoprotective capability of PL has been proven in a multitude of in vitro and in vivo studies, which include animal models and clinical trials with human subjects. Based on this evidence, PL is a new generation photoprotector with antioxidant and anti-inflammatory properties that also protects DNA integrity and enhances the immune response.

中文翻译:

水性提取物白头翁在光保护中的作用。

紫外线(UV),可见光(VIS)和红外(IR)范围内的太阳辐射会对人类产生不同的生物效应。这些中的大多数,特别是那些来自紫外线(UVR)的物质,对皮肤有害,包括皮肤老化和皮肤疾病,特别是皮肤癌的风险增加。药理光保护主要是局部用药,但也可以是全身用药。口服光防护剂构成了对抗太阳辐射有害作用的新一代药物。其中,白毛提取物(PL /Fernblock®,IFC集团,西班牙)含有高含量的酚类化合物,使其具有抗氧化活性。PL可以口服或局部给药,是完全安全的。PL通过中和超氧阴离子,羟基自由基和脂过氧化物来补充和增强内源性抗氧化剂系统。除具有抗氧化活性外,PL还改善了DNA修复并调节了免疫和炎症反应。这些活动可能归因于其通过UVR,VIS和IR辐射抑制活性氧(ROS)生成和释放的能力。PL还通过加速去除诱导的光产物并减少UV诱导的突变来防止直接的DNA损伤。口服PL可增加活性p53的表达,减少细胞增殖,并抑制UV诱导的COX-2酶水平。PL已被用于治疗皮肤疾病,例如光皮病和色素性疾病,最近还被用作光化性角化病中光动力光疗的补充。PL的光保护能力已在众多体外体内研究,包括动物模型和人类受试者的临床试验。基于这一证据,PL是具有抗氧化剂和抗炎特性的新一代光保护剂,它还可以保护DNA完整性并增强免疫反应。
更新日期:2020-05-14
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