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Physiological responses to maximal eating in men
British Journal of Nutrition ( IF 3.6 ) Pub Date : 2020-04-06 , DOI: 10.1017/s0007114520001270 Aaron Hengist 1 , Robert M Edinburgh 1 , Russell G Davies 1 , Jean-Philippe Walhin 1 , Jariya Buniam 1, 2 , Lewis J James 3 , Peter J Rogers 4, 5 , Javier T Gonzalez 1 , James A Betts 1
British Journal of Nutrition ( IF 3.6 ) Pub Date : 2020-04-06 , DOI: 10.1017/s0007114520001270 Aaron Hengist 1 , Robert M Edinburgh 1 , Russell G Davies 1 , Jean-Philippe Walhin 1 , Jariya Buniam 1, 2 , Lewis J James 3 , Peter J Rogers 4, 5 , Javier T Gonzalez 1 , James A Betts 1
Affiliation
This study investigated metabolic, endocrine, appetite and mood responses to a maximal eating occasion in fourteen men (mean: age 28 (sd 5) years, body mass 77·2 (sd 6·6) kg and BMI 24·2 (sd 2·2) kg/m2 ) who completed two trials in a randomised crossover design. On each occasion, participants ate a homogenous mixed-macronutrient meal (pizza). On one occasion, they ate until ‘comfortably full’ (ad libitum ) and on the other, until they ‘could not eat another bite’ (maximal). Mean energy intake was double in the maximal (13 024 (95 % CI 10 964, 15 084) kJ; 3113 (95 % CI 2620, 3605) kcal) compared with thead libitum trial (6627 (95 % CI 5708, 7547) kJ; 1584 (95 % CI 1364, 1804) kcal). Serum insulin incremental AUC (iAUC) increased approximately 1·5-fold in the maximal compared withad libitum trial (mean:ad libitum 43·8 (95 % CI 28·3, 59·3) nmol/l × 240 min and maximal 67·7 (95 % CI 47·0, 88·5) nmol/l × 240 min,P < 0·01), but glucose iAUC did not differ between trials (ad libitum 94·3 (95 % CI 30·3, 158·2) mmol/l × 240 min and maximal 126·5 (95 % CI 76·9, 176·0) mmol/l × 240 min,P = 0·19). TAG iAUC was approximately 1·5-fold greater in the maximalv .ad libitum trial (ad libitum 98·6 (95 % CI 69·9, 127·2) mmol/l × 240 min and maximal 146·4 (95 % CI 88·6, 204·1) mmol/l × 240 min,P < 0·01). Total glucagon-like peptide-1, glucose-dependent insulinotropic peptide and peptide tyrosine–tyrosine iAUC were greater in the maximal compared withad libitum trial (P < 0·05). Total ghrelin concentrations decreased to a similar extent, but AUC was slightly lower in the maximalv .ad libitum trial (P = 0·02). There were marked differences on appetite and mood between trials, most notably maximal eating caused a prolonged increase in lethargy. Healthy men have the capacity to eat twice the energy content required to achieve comfortable fullness at a single meal. Postprandial glycaemia is well regulated following initial overeating, with elevated postprandial insulinaemia probably contributing.
中文翻译:
男性对最大摄入量的生理反应
这项研究调查了 14 名男性(平均:28 岁(sd 5)年,体重77·2(sd 6·6) kg 和 BMI 24·2 (sd 2·2) 公斤/米2 ) 在随机交叉设计中完成了两项试验。每次,参与者都吃一顿均质的混合宏量营养素餐(比萨饼)。有一次,他们吃到“舒服地饱”(随意 ),另一方面,直到他们“不能再吃一口”(最大)。最大平均能量摄入量(13 024 (95 % CI 10 964, 15 084) kJ; 3113 (95 % CI 2620, 3605) kcal)是随意 试验 (6627 (95 % CI 5708, 7547) kJ; 1584 (95 % CI 1364, 1804) kcal)。血清胰岛素增量 AUC (iAUC) 最大增加约 1·5 倍随意 审判(意思是:随意 43·8 (95 % CI 28·3, 59·3) nmol/l × 240 min 和最大 67·7 (95 % CI 47·0, 88·5) nmol/l × 240 min,磷 < 0·01),但试验之间的葡萄糖 iAUC 没有差异(随意 94·3 (95 % CI 30·3, 158·2) mmol/l × 240 min 和最大 126·5 (95 % CI 76·9, 176·0) mmol/l × 240 min,磷 = 0·19)。TAG iAUC 的最大值约为 1·5 倍v .随意 审判 (随意 98·6 (95 % CI 69·9, 127·2) mmol/l × 240 min 和最大 146·4 (95 % CI 88·6, 204·1) mmol/l × 240 min,磷 < 0·01)。总胰高血糖素样肽-1、葡萄糖依赖性促胰岛素肽和肽酪氨酸-酪氨酸 iAUC 的最大值与随意 审判 (磷 < 0·05)。总生长素释放肽浓度以相似的程度下降,但 AUC 在最大值时略低v .随意 审判 (磷 = 0·02)。试验之间的食欲和情绪存在显着差异,最明显的是最大量进食导致嗜睡延长。健康的男性在一顿饭中摄入的能量是达到舒适饱腹所需能量的两倍。最初暴饮暴食后,餐后血糖得到很好的调节,可能与餐后胰岛素血症升高有关。
更新日期:2020-04-06
中文翻译:
男性对最大摄入量的生理反应
这项研究调查了 14 名男性(平均:28 岁(