The intravenous administration of a formulation of interleukin-12 that binds to collagen in established ‘immunologically cold’ murine tumours enhances interferon-γ production by T cells and causes tumour remission, especially when in combination with immune checkpoint blockade therapy.

中文翻译：

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结合胶原蛋白的IL-12会引起“冷”肿瘤。

在已建立的“免疫寒冷”鼠类肿瘤中，静脉注射与胶原蛋白结合的白介素12制剂可增强T细胞产生的干扰素-γ并引起肿瘤缓解，尤其是与免疫检查点封锁疗法联合使用时。