Testosterone is the predominant androgen in men and the lack of it can be a trigger to the development of the metabolic syndrome. Here we review the relationship between testosterone deficiency, metabolic syndrome, and hepatic steatosis reported by studies with men and rodents. The prevalence of metabolic syndrome and testosterone deficiency is higher among older subjects. Low total and free testosterone levels were positively associated with disturbs on energy metabolism, changes in body fat distribution, and body composition. Studies reported visceral fat accumulation in men with hypogonadism and castrated rats. Despite some contradictions, the association between higher adiposity, low testosterone, and metabolic syndrome was a common point among the studies. Few studies evaluated the hepatic steatosis and found an association with hypogonadism. Most of the studies with rodents combined the castration with a high-fat diet to study metabolic disturbs. The importance of proper levels of testosterone for energy metabolism homeostasis in men was also underlined by studies that investigated the metabolic effects of testosterone replacement therapy and androgen deprivation therapy.

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代谢综合征、肝脂肪变性和睾酮缺乏之间的关联：来自男性和啮齿动物研究的证据。

睾酮是男性主要的雄激素，缺乏睾酮可能会引发代谢综合征的发展。在这里，我们回顾了男性和啮齿动物研究报告的睾酮缺乏、代谢综合征和肝脂肪变性之间的关系。代谢综合征和睾酮缺乏症的患病率在老年受试者中更高。低总睾酮和游离睾酮水平与能量代谢紊乱、体脂分布变化和身体成分呈正相关。研究报告了男性性腺功能减退症和阉割大鼠的内脏脂肪堆积。尽管存在一些矛盾，但高肥胖、低睾酮和代谢综合征之间的关联是研究中的一个共同点。很少有研究评估肝脏脂肪变性并发现与性腺机能减退有关。大多数对啮齿动物的研究将阉割与高脂肪饮食相结合来研究代谢紊乱。研究睾酮替代疗法和雄激素剥夺疗法的代谢影响的研究也强调了适当水平的睾酮对男性能量代谢稳态的重要性。