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Systematic Investigations on Continuous Fluidized Bed Crystallization for Chiral Separation
Crystals ( IF 2.7 ) Pub Date : 2020-05-14 , DOI: 10.3390/cryst10050394
Erik Temmel , Jonathan Gänsch , Andreas Seidel-Morgenstern , Heike Lorenz

A recently developed continuous enantioseparation process utilizing two coupled fluidized bed crystallizers is systematically investigated to identify essential correlations between different operation parameters and the corresponding process performance on the example of asparagine monohydrate. Based on liquid phase composition and product crystal size distribution data, it is proven that steady state operation is achieved reproducibly in a relatively short time. The process outputs at steady state are compared for different feed flow rates, supersaturations, and crystallization temperatures. It is shown that purities >97% are achieved with productivities up to 40 g/L/h. The size distribution, which depends almost exclusively on the liquid flow rate, can be easily adjusted between 260 and 330 µm (mean size) with an almost constant standard deviation of ±55 µm.

中文翻译:

用于手性分离的连续流化床结晶的系统研究

系统研究了利用两个耦合的流化床结晶器的最近开发的连续对映体分离工艺,以天冬酰胺一水合物为例,确定了不同操作参数与相应工艺性能之间的本质相关性。基于液相组成和产物晶体尺寸分布数据,证明了在相对短的时间内可再现地达到稳态操作。比较不同进料流量,过饱和度和结晶温度下稳态下的过程输出。结果表明,生产率高达40 g / L / h时,纯度> 97%。尺寸分布几乎完全取决于液体流量,
更新日期:2020-05-14
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