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Preconception Risk Factors for Autism Spectrum Disorder - A Pilot Study.
Brain Sciences ( IF 3.3 ) Pub Date : 2020-05-14 , DOI: 10.3390/brainsci10050293
Hankus Magdalena 1 , Kazek Beata 2 , Justyna Paprocka 1 , Kapinos-Gorczyca Agnieszka 3 , Magdalena Szczepara-Fabian 4 , Agata Buczek 5 , Emich-Widera Ewa 1
Affiliation  

Autism spectrum disorder (ASD) is a neurodevelopmental disorder of multifactorial etiology. Preconception risk factors are still poorly understood. A survey on preconception risk factors for ASD was conducted among parents of 121 ASD patients aged 3-12 years and parents of 100 healthy children aged 3-12 years. The exclusion criteria were as follows: the presence of associated problems such as intellectual disability, epilepsy or other genetic and neurological diseases. Thirteen parameters were considered, a few among which were conception problems, conception with assisted reproductive techniques, the use and duration of oral contraception, the number of previous pregnancies and miscarriages, time since the previous pregnancy (in months), the history of mental illness in the family (including ASD), other chronic diseases in the mother or father and maternal and paternal treatment in specialist outpatient clinics. Three factors statistically significantly increased the risk of developing ASD: mental illness in the mother/mother's family (35.54% vs. 16.0%, p = 0.0002), maternal thyroid disease (16.67% vs. 5.0%, p = 0.009) and maternal oral contraception (46.28% vs. 29.0%, p = 0.01). Children of mothers with thyroid disorders or with mental illness in relatives should be closely monitored for ASD. Further studies are warranted to assess a potential effect of oral contraception on the development of offspring.

中文翻译:

自闭症谱系的先验风险因素-一项初步研究。

自闭症谱系障碍(ASD)是一种多因素病因的神经发育障碍。孕前危险因素仍知之甚少。在121名年龄在3-12岁的ASD患者的父母和100名年龄在3-12岁的健康儿童的父母之间进行了一项关于ASD先孕危险因素的调查。排除标准如下:存在相关问题,例如智力残疾,癫痫或其他遗传和神经系统疾病。考虑了13个参数,其中一些是怀孕问题,辅助生殖技术的怀孕,口服避孕药的使用和持续时间,以前怀孕和流产的次数,自上次怀孕以来的时间(以月为单位),精神病史在家庭中(包括ASD),母亲或父亲的其他慢性病以及专科门诊的母婴治疗。从统计上看,三个因素显着增加了患自闭症的风险:母亲/母亲家庭中的精神疾病(35.54%vs. 16.0%,p = 0.0002),母亲甲状腺疾病(16.67%vs. 5.0%,p = 0.009)和母亲口服避孕(46.28%对29.0%,p = 0.01)。患有甲状腺疾病或患有亲属精神疾病的母亲的孩子应密切监测其ASD。有必要做进一步的研究来评估口服避孕药对后代发育的潜在影响。孕妇甲状腺疾病(16.67%vs. 5.0%,p = 0.009)和孕妇口服避孕药(46.28%vs. 29.0%,p = 0.01)。患有甲状腺疾病或患有亲属精神疾病的母亲的孩子应密切监测其ASD。有必要做进一步的研究来评估口服避孕药对后代发育的潜在影响。孕妇甲状腺疾病(16.67%vs. 5.0%,p = 0.009)和孕妇口服避孕药(46.28%vs. 29.0%,p = 0.01)。患有甲状腺疾病或患有亲属精神疾病的母亲的孩子应密切监测其ASD。有必要做进一步的研究来评估口服避孕药对后代发育的潜在影响。
更新日期:2020-05-14
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