Background We conducted this systematic review and meta-analysis to evaluate the latest evidence on the association between cerebrovascular, cardiovascular disease, and poor outcome in patients with Coronavirus Disease 2019 (COVID-19) pneumonia. Methods A comprehensive systematic literature search was performed using PubMed, SCOPUS, EuropePMC, and Cochrane Central Database. The outcome of interest was composite poor outcome that comprised of mortality and severe COVID-19. Results A total of 4448 patients were obtained from 16 studies. Cerebrovascular disease was associated with increased poor composite outcome (RR 2.04 [1.43, 2.91], p<0.001; I2: 77%). Subgroup analysis revealed that cerebrovascular disease was associated with mortality (RR 2.38 [1.92, 2.96], p<0.001; I2: 0%) and was borderline significant for severe COVID-19 (RR 1.88 [1.00, 3.51], p=0.05; I2: 87%). Cardiovascular disease was associated with increased composite poor outcome (RR 2.23 [1.71, 2.91], p<0.001; I2: 60%), and its mortality (RR 2.25 [1.53, 3.29], p<0.001; I2: 33%) and severe COVID-19 (RR 2.25 [1.51, 3.36], p<0.001; I2: 76%) subgroup. Meta-regression demonstrate that the association was not influenced by gender, age, hypertension, diabetes, and respiratory comorbidities. The association between cerebrovascular disease and poor outcome was not affected by cardiovascular diseases and vice versa. Conclusion Cerebrovascular and cardiovascular diseases were associated with increased risk for poor outcome in COVID-19.

中文翻译：

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脑血管和心血管疾病对 COVID-19 死亡率和严重程度的影响 - 系统评价、荟萃分析和荟萃回归。

背景我们进行了这项系统回顾和荟萃分析，以评估关于脑血管、心血管疾病与 2019 年冠状病毒病 (COVID-19) 肺炎患者预后不良之间关联的最新证据。方法 使用 PubMed、SCOPUS、EuropePMC 和 Cochrane 中央数据库进行全面系统的文献检索。感兴趣的结果是由死亡率和严重的 COVID-19 组成的复合不良结果。结果 16 项研究共纳入 4448 名患者。脑血管疾病与不良综合结局增加相关（RR 2.04 [1.43, 2.91]，p<0.001；I2：77%）。亚组分析显示，脑血管疾病与死亡率相关（RR 2.38 [1.92, 2.96]，p<0.001；I2：0%），并且对于重症 COVID-19 具有临界显着性（RR 1.88 [1.00, 3.51]，p=0.05；I2：0%）。 I2：87%）。心血管疾病与复合不良结局增加相关（RR 2.23 [1.71, 2.91]，p<0.001；I2：60%）及其死亡率（RR 2.25 [1.53，3.29]，p<0.001；I2：33%）和重症 COVID-19（RR 2.25 [1.51, 3.36]，p<0.001；I2：76%）亚组。荟萃回归表明，这种关联不受性别、年龄、高血压、糖尿病和呼吸系统合并症的影响。脑血管疾病与不良预后之间的关联不受心血管疾病的影响，反之亦然。结论 脑血管和心血管疾病与 COVID-19 预后不良的风险增加相关。