This study aimed to develop a simple method for synthesis of vitamin c-coated selenium nanoparticles which were then labeled with technetium-99m for further in vivo studies on normal and solid tumor induced mice. Results showed the formation of amorphous SeNPs with a mean size of (23 ± 5 nm). The radiolabelling yield of [ 99m Tc-Vit_C (SeNPs)] was (96 ± 2%) with stability up to 6 h. Effective target non-target ratios were obtained in solid tumor-induced mice throughout the experimental time points. [ 99m Tc-Vit_C (SeNPs)] complex showed promising features which make it a potential radiopharmaceutical for imaging of solid tumors.

中文翻译：

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维生素 C 稳定的硒纳米颗粒的合成和放射性标记作为诊断实体瘤的一种有前途的方法

本研究旨在开发一种简单的方法来合成维生素 c 包覆的硒纳米颗粒，然后用锝-99m 标记，用于对正常和实体肿瘤诱导的小鼠进行进一步的体内研究。结果显示形成平均尺寸为 (23 ± 5 nm) 的无定形 SeNP。[ 99m Tc-Vit_C (SeNPs)] 的放射性标记率为 (96 ± 2%)，稳定性长达 6 小时。在整个实验时间点，在实体瘤诱导的小鼠中获得了有效的靶标非靶标比率。[ 99m Tc-Vit_C (SeNPs)] 复合物显示出有前景的特性，使其成为用于实体瘤成像的潜在放射性药物。