HemoDose is a software tool, which estimates absorbed doses based on blood cell counts (BCC). The aim of our study was to validate HemoDose for early dose estimates. Dose estimates generated by HemoDose were compared with dose estimates stored in SEARCH from radiation victims. Moreover, BCC from unirradiated donors and corresponding HemoDose dose estimates were analysed. We employed linear or logistic regression analysis. There was a significant correlation between calculated doses by HemoDose based on single and multiple lymphocyte counts when omitting lowest and highest dose estimates. Furthermore, there was a significant correlation between calculated doses by HemoDose based on lymphocyte counts and the estimated doses based on DIC. The dose estimates by HemoDose based on lymphocyte counts and DIC showed a comparable correlation with HARS degrees 0 and 4. In conclusion, HemoDose dose estimation based on early lymphocyte counts appears to be a promising biodosimetry tool under certain considerations.

中文翻译：

---

使用局部剂量估计值和早期辐射诱发的真实细胞历史的血细胞计数变化来验证过血量生物计量学工具。

HemoDose是一个软件工具，可以根据血细胞计数（BCC）估算吸收剂量。我们研究的目的是验证HemoDose的早期剂量估计。将HemoDose生成的剂量估算值与存储在SEARCH中的辐射受害者的剂量估算值进行比较。此外，分析了来自未辐射供体的BCC和相应的HemoDose剂量估计。我们采用线性或逻辑回归分析。当省略最低和最高剂量估算值时，基于单个和多个淋巴细胞计数的HemoDose计算剂量之间存在显着相关性。此外，HemoDose基于淋巴细胞计数的估计剂量与基于DIC的估计剂量之间存在显着相关性。