Distortion product otoacoustic emission (DPOAE) maps collect DPOAE emissions over a broad range of frequencies and ratios. One application of DPOAE mapping could be monitoring changes in intracranial pressure (ICP) in space, where non-invasive measures of ICP are an area of interest. Data were collected in two experiments to statistically assess changes in DPOAE maps. A repeatability study where four maps per subject were collected across four weeks to establish “normal” variability in DPOAE data, and a posture study where subjects were measured supine and prone with lower body negative pressure, lower body positive pressure (LBPP), and at atmospheric pressure. DPOAE amplitude maps were analyzed using statistical parametric mapping and random field theory. Postural changes produced regional changes in the maps, specifically in the range of 5–7.5 kHz and between primary tone ratios of 1.13–1.24. These regional changes were most pronounced in the prone LBPP condition, where amplitudes were lower from baseline for the Postural Cohort than the Repeatability Cohort. Statistical parametric mapping provided a sensitive measure of regional DPOAE map changes, which may be useful clinically to monitor ICP noninvasively in individuals or for research to identify differences within in cohorts of people.

中文翻译：

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使用统计参数映射和随机场理论检测失真产物耳声发射图的变化。

失真产物耳声发射（DPOAE）图收集了广泛的频率和比率范围内的DPOAE发射。DPOAE绘图的一种应用可以是监视空间中颅内压（ICP）的变化，而ICP的非侵入性测量是其中一个令人关注的领域。在两个实验中收集数据，以统计学方式评估DPOAE图的变化。在四个星期内收集每个受试者四张地图以建立DPOAE数据“正常”变异性的可重复性研究，以及在姿势下进行仰卧和俯卧测量的受试者的下身负压，下身正压（LBPP）和气压。使用统计参数映射和随机场理论分析DPOAE振幅图。姿势变化在地图上产生了区域变化，特别是在5-7范围内。5 kHz，且介于1.13–1.24之间。这些区域变化在俯卧的LBPP条件下最为明显，其中姿势队列的幅度比基线低，而重复性队列则较基线低。统计参数映射为区域DPOAE映射变化提供了灵敏的度量，这在临床上可用于非侵入性地监测个体的ICP或用于研究识别人群中的差异的临床方法。