BACKGROUND Preeclampsia leads to chronic intrauterine hypoxia by interfering with placental blood supply. We aimed to investigate whether preeclampsia exposure has an influence on central nervous system of infants, as evaluated by analyzing neonatal serum neuron specific enolase (NSE). METHODS This was a retrospective study including infants born in Nanfang hospital between Jan 2018 and Feb 2019 without asphyxia. They were divided into normotensive control group and preeclampsia group to compare the NSE levels. Furthermore, PE group was divided into five subgroups by lipstick of urine protein from 0 to 4+ to examine the relationship between urine protein and neonatal NSE. RESULTS Of the 86 selected neonates, there were 40 in control group and 46 in preeclampsia group. The NSE levels were significantly higher in infants with preeclampsia exposure compared to those infants in control group (45.504 ± 17.926 vs 30.690 ± 4.475, P < 0.0001). Multiple regression analyses revealed that the preeclampsia (β coef = 0.394, p = 0.041), 4+ proteinuria (β coef = 0.558, p < 0.0001) and 3+ proteinuria (β coef = 0.356, p = 0.005) were significant independent variables predicting elevated serum NSE concentration. CONCLUSION For the first time, this research has suggested the increase of neonatal NSE in preeclampsia, and the quantity of maternal proteinuria may be able to predict neonatal NSE elevation. Long-term neurodevelopmental follow-up and targeted preventive strategies are advised for this underrecognized high-risk population.

中文翻译：

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新生儿神经元特异性烯醇化酶是神经元损伤的敏感生化标志物，在先兆子痫中增加：一项回顾性队列研究

背景先兆子痫通过干扰胎盘血液供应导致慢性宫内缺氧。我们旨在通过分析新生儿血清神经元特异性烯醇化酶 (NSE) 评估先兆子痫暴露是否对婴儿的中枢神经系统有影响。方法回顾性研究2018年1月至2019年2月在南方医院出生的无窒息婴儿。分为血压正常对照组和子痫前期组比较NSE水平。此外，PE组根据尿蛋白口红从0到4+分为五个亚组，以考察尿蛋白与新生儿NSE的关系。结果86例入选新生儿中，对照组40例，子痫前期组46例。与对照组婴儿相比，先兆子痫暴露婴儿的 NSE 水平显着更高（45.504 ± 17.926 vs 30.690 ± 4.475，P < 0.0001）。多元回归分析显示先兆子痫 (β coef = 0.394, p = 0.041)、4+ 蛋白尿 (β coef = 0.558, p < 0.0001) 和 3+ 蛋白尿 (β coef = 0.356, p = 0.005) 是重要的预测独立变量血清 NSE 浓度升高。结论 本研究首次提示子痫前期新生儿NSE升高，且母体蛋白尿量可预测新生儿NSE升高。对于这一未被充分认识的高危人群，建议进行长期的神经发育随访和有针对性的预防策略。多元回归分析显示先兆子痫 (β coef = 0.394, p = 0.041)、4+ 蛋白尿 (β coef = 0.558, p < 0.0001) 和 3+ 蛋白尿 (β coef = 0.356, p = 0.005) 是重要的预测独立变量血清 NSE 浓度升高。结论 本研究首次提示子痫前期新生儿NSE升高，且母体蛋白尿量可预测新生儿NSE升高。对于这一未被充分认识的高危人群，建议进行长期的神经发育随访和有针对性的预防策略。多元回归分析显示先兆子痫 (β coef = 0.394, p = 0.041)、4+ 蛋白尿 (β coef = 0.558, p < 0.0001) 和 3+ 蛋白尿 (β coef = 0.356, p = 0.005) 是重要的预测独立变量血清 NSE 浓度升高。结论本研究首次提示子痫前期新生儿NSE升高，且母体蛋白尿量可预测新生儿NSE升高。对于这一未被充分认识的高危人群，建议进行长期的神经发育随访和有针对性的预防策略。结论 本研究首次提示子痫前期新生儿NSE升高，且母体蛋白尿量可预测新生儿NSE升高。对于这一未被充分认识的高危人群，建议进行长期的神经发育随访和有针对性的预防策略。结论 本研究首次提示子痫前期新生儿NSE升高，且母体蛋白尿量可预测新生儿NSE升高。对于这一未被充分认识的高危人群，建议进行长期的神经发育随访和有针对性的预防策略。