Abstract

Objective: The primary aim of this study was to evaluate the scientific evidence supporting the use of thermal dose as a secondary (or an alternative) endpoint when using the CoreTherm Concept.

Material and methods: Baseline and treatment data from 283 consecutive treatments were evaluated. All patients had lower urinary tract symptoms (LUTS) caused by benign prostatic hyperplasia (BPH). After evaluation, benign prostatic enlargement (BPE) with benign prostatic obstruction (BPO) was evident. As treatment, the CoreTherm Concept was used in all patients with LUTS/BPO. Data parameters were retrospectively extracted and included patient age, prostate volume, energy delivery, treatment time and calculated cell kill. In addition, assessment of temperature curves and calculated intraprostatic blood flow was made to define an optimal treatment. In total, 199 treatments assessed as optimal were included in the study.

Results: There was a significant correlation between pretreatment prostate volume and energy delivery (p < .001). Age also influenced energy consumption significantly (p = .01).

Conclusion: The solid correlation between pretreatment prostate volume and age versus total energy deposition implies the recommendation that a pretreatment calculation of an appropriate energy deposition should be used in all treatments as an alternative treatment endpoint.

摘要

目的：本研究的主要目的是评估使用CoreTherm Concept时支持将热剂量用作次要（或替代）终点的科学证据。

材料和方法：评估了连续283次治疗的基线和治疗数据。所有患者均具有由前列腺增生（BPH）引起的下尿路症状（LUTS）。经过评估，良性前列腺肥大（BPE）伴有良性前列腺梗阻（BPO）。作为治疗，CoreTherm Concept用于所有LUTS / BPO患者。回顾性地提取数据参数，包括患者年龄，前列腺体积，能量传递，治疗时间和计算的细胞杀伤率。另外，评估温度曲线和计算出的前列腺内血流量以定义最佳治疗。该研究总共包括199种被评估为最佳治疗方法。

结果：预处理前列腺体积与能量输送之间存在显着相关性（p  <.001）。年龄也显着影响能量消耗（p  = 0.01）。

结论：预处理前列腺体积和年龄与总能量沉积之间的牢固相关性暗示建议在所有治疗中均应使用适当能量沉积的预处理计算作为替代治疗终点。