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C-reactive protein, interleukin-6 and pre-eclampsia: large-scale evidence from the GenPE case-control study.
Scandinavian Journal of Clinical and Laboratory Investigation ( IF 2.1 ) Pub Date : 2020-05-13 , DOI: 10.1080/00365513.2020.1747110
Norma C Serrano 1, 2 , Elizabeth Guio 1 , Silvia M Becerra-Bayona 3 , Doris C Quintero-Lesmes 1 , Paula K Bautista-Niño 1 , Claudia Colmenares-Mejía 1 , María C Páez 3 , María L Luna 3 , Luis A Díaz 4 , Ricardo Ortiz 3 , Mónica Beltrán 3, 4 , Álvaro Monterrosa 5 , Yezid Miranda 5 , Clara M Mesa 6 , Wilmar Saldarriaga 7 , Juan P Casas 8
Affiliation  

Multiple small studies have suggested that women with pre-eclampsia present elevated levels of C-reactive protein (CRP) and interleukin-6 (IL-6). However, little is known regarding the source of this CRP and IL-6 increase. Therefore, the aim of this study was to evaluate the relationship between CRP and IL-6 levels with pre-eclampsia considering different confounding factors. Using data from a large Colombian case-control study (3,590 cases of pre-eclampsia and 4,564 normotensive controls), CRP and IL-6 levels were measured in 914 cases and 1297 controls. The association between maternal serum levels of CRP and IL-6 with pre-eclampsia risk was evaluated using adjusted logistic regression models. Pre-eclampsia was defined as presence of blood pressure ≥140/90 mmHg and proteinuria ≥300mg/24 h (or ≥1 + dipstick). There was no evidence of association between high levels of CRP and IL-6 with pre-eclampsia after adjusting for the following factors: maternal and gestational age, ethnicity, place and year of recruitment, multiple-pregnancy, socio-economic position, smoking, and presence of infections during pregnancy. The adjusted OR for 1SD increase in log-CRP and log-IL-6 was 0.96 (95%CI 0.85, 1.08) and 1.09 (95%CI 0.97, 1.22), respectively. Although previous reports have suggested an association between high CRP and IL-6 levels with pre-eclampsia, sample size may lack the sufficient power to draw robust conclusions, and this association is likely to be explained by unaccounted biases. Our results, the largest case-control study reported up to date, demonstrate that there is not a causal association between elevated levels of CRP and IL-6 and the presence of pre-eclampsia.



中文翻译:

C反应蛋白,白介素6和先兆子痫:GenPE病例对照研究的大量证据。

多项小型研究表明,患有先兆子痫的妇女的C反应蛋白(CRP)和白介素6(IL-6)的水平升高。然而,关于这种CRP和IL-6增加的来源知之甚少。因此,本研究的目的是在考虑不同混杂因素的情况下评估子痫前期CRP和IL-6水平之间的关系。利用哥伦比亚大型病例对照研究(3,590例先兆子痫和4,564例正常血压对照)的数据,对914例和1297例对照进行了CRP和IL-6水平的测量。使用调整的逻辑回归模型评估孕妇血清CRP和IL-6水平与先兆子痫风险之间的关系。子痫前期被定义为存在血压≥140/ 90 mmHg,蛋白尿≥300mg/ 24 h(或≥1+量油尺)。在调整以下因素后,没有证据表明高水平的CRP和IL-6与先兆子痫之间存在关联:母体和胎龄,种族,征聘地点和年份,多胎妊娠,社会经济地位,吸烟,怀孕期间是否有感染。log-CRP和log-IL-6中1SD的调整后OR分别为0.96(95%CI 0.85,1.08)和1.09(95%CI 0.97,1.22)。尽管先前的报告表明高CRP和IL-6水平与先兆子痫之间存在关联,但样本量可能不足以得出可靠的结论,并且这种关联很可能由无法解释的偏见来解释。我们的结果是迄今为止最大的病例对照研究报告,

更新日期:2020-05-13
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