Although an electrohypersensitivity (EHS) is reported in numerous studies, some authors associate hyperfrequencies (HF)-related pains with a nocebo effect while others suggest a biological effect. Therefore, we aimed to suggest hypotheses about the complex mechanisms of headaches related to HF-exposure. We crossed basic features of headaches with relevant studies (from the year 2000 up to 2018) emphasizing on the HF effects that may lead to pain genesis: neuroglial dysmetabolism, neuroinflammation, changes in cerebral blood perfusion, blood-brain barrier dysfunction and electrophysiological evidences of hyperexcitability. We privileged studies implying a sham exposure (for in vivo studies) and a specific absorption rate lower than 4 W/Kg. HF-induced headaches may involve an indirect inflammatory process (neurogenic, magnetogenic or thermogenic) as well as a direct biophysical effect (thermogenic or magnetogenic). We linked inflammatory processes to meningeal dysperfusion or primary neuroglial dysfunction triggered by non-thermal irradiation or HF-induced heating at thermal powers. In the latter case, HF-induced excitoxicity and oxidative stress probably play a crucial role. Such disorders may lead to vascular-trigeminal activation in predisposed people. Interestingly, an abnormal oxidative stress predisposition had been demonstrated in overall 80% of EHS self-reporting patients. In the case of direct effects, pain pathways’ activation may be directly triggered by HF-irradiation (heating and/or transcranial HF-induced ectopic action potentials). Further research on HF-related headaches is needed.

尽管在许多研究中都报告了电超敏性（EHS），但一些作者将与高频（HF）相关的疼痛与Nocebo效应相关联，而另一些人则提出了生物学效应。因此，我们旨在提出有关与HF暴露相关的头痛的复杂机制的假设。我们将头痛的基本特征与相关研究（从2000年到2018年）进行了交叉研究，强调可能导致疼痛发生的心衰效应：神经胶质代谢障碍，神经炎症，脑血流灌注变化，血脑屏障功能障碍和电生理学证据过度兴奋。我们优先进行隐含暴露（用于体内研究）且比吸收率低于4 W / Kg的研究。HF诱发的头痛可能涉及间接的炎症过程（神经源性，磁生或生热）以及直接的生物物理效应（生热或生磁）。我们将炎性过程与由非热辐射或由HF诱导的热能引发的脑膜灌注不足或原发性神经胶质功能障碍联系起来。在后一种情况下，HF引起的兴奋性中毒和氧化应激可能起关键作用。这类疾病可能导致易感人群中的血管三叉神经激活。有趣的是，已经在80％的EHS自报告患者中证实了异常的氧化应激倾向。在直接作用的情况下，疼痛路径的激活可能是由HF辐射（加热和/或经颅HF诱导的异位动作电位）直接触发的。需要进一步研究与HF相关的头痛。