Objective: To determine the incidence of venous thromboembolism (VTE) in patients with acute cervical spinal cord injury (SCI) and ossification of the posterior longitudinal ligament (OPLL).

Design: Prospective cohort study.

Setting: A department of a university hospital in Japan.

Participants: This study included 57 patients (OPLL, n = 10; non-OPLL, n = 47) treated for acute cervical SCI between January 2011 and April 2017. Patients were classified according to motor complete paralysis (MC), motor incomplete paralysis (MIC), or normal motor function, based on American Spinal Injury Association (ASIA) Impairment Scale results.

Interventions: N/A.

Outcome Measures: All patients were screened for VTE by D-dimer monitoring, and some underwent ultrasonography. If ultrasonography indicated deep venous thrombosis (DVT) or if the D-dimers increased to ≥10 µg/mL, patients underwent contrast venography to detect VTE, including DVT or pulmonary embolism. We compared blood coagulability and VTE incidence in the OPLL and non-OPLL groups.

Results: VTE occurred in 11 (19.3%) of 57 patients. The incidence of VTE was higher in the OPLL group than in the non-OPLL group (50% vs. 12.8%; P = 0.017) and higher in the MC group (57.1%) than in the MIC (8.3%; P = 0.002) or normal group (5.3%; P = 0.002). In the MC group, VTE occurred in 50% of OPLL patients and in 62.5% of non-OPLL patients (P = 0.529). In the MIC group, VTE occurred in 50% of OPLL patients and in none of the non-OPLL patients (P = 0.022).

Conclusions: Patients with OPLL tended to develop VTE after SCI with motor complete and incomplete paralysis.

目的：确定急性颈脊髓损伤（SCI）和后纵韧带骨化（OPLL）患者的静脉血栓栓塞（VTE）发生率。

设计：前瞻性队列研究。

地点：日本大学医院的一个科室。

参与者：这项研究包括2011年1月至2017年4月之间接受急性宫颈SCI治疗的57例患者（OPLL，n = 10；非OPLL，n = 47）。 MIC）或正常运动功能，基于美国脊髓损伤协会（ASIA）损伤量表的结果。

干预措施： N / A。

结果测量：所有患者均通过D-二聚体监测筛查VTE，部分患者接受了超声检查。如果超声检查显示深静脉血栓形成（DVT）或D-二聚体增加至≥10 µg / mL，则患者应进行对比静脉造影以检测VTE，包括DVT或肺栓塞。我们比较了OPLL和非OPLL组的血液凝固性和VTE发生率。

结果： 57例患者中有11例（19.3％）发生了VTE。OPLL组的VTE发生率高于非OPLL组（50％vs. 12.8％; P = 0.017），而MC组（57.1％）高于MIC（8.3％; P = 0.002） ）或正常组（5.3％； P = 0.002）。在MC组中，VTE发生在50％的OPLL患者和62.5％的非OPLL患者中（P = 0.529）。在MIC组中，VTE发生在50％的OPLL患者中，没有一个发生在非OPLL患者中（P = 0.022）。

结论： OPLL患者在SCI后出现运动性完全和不完全麻痹的VTE。