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Poly(Caprolactone Fumarate) and Oligo[Poly(Ethylene Glycol) Fumarate]: Two Decades of Exploration in Biomedical Applications
Polymer Reviews ( IF 13.1 ) Pub Date : 2020-05-04 , DOI: 10.1080/15583724.2020.1758718
Bipin Gaihre 1, 2 , Xifeng Liu 1, 2 , A. Lee Miller 2 , Michael Yaszemski 1, 2 , Lichun Lu 1, 2
Affiliation  

The past few decades have seen a significant interest in the fumarate-based polymers for biomedical applications. Poly(caprolactone fumarate) (PCLF) and oligo[poly(ethylene glycol) fumarate] (OPF) are derivatives of polycaprolactone and polyethylene glycol respectively, which are rendered cross-linkable, biodegradable, and possess tunable mechanical properties by the introduction of unsaturated fumarate groups. PCLF is a hydrophobic polymer, mostly applied as pre-formed or 3-D printed scaffolds while OPF is an aqueous-solvent based polymer mostly explored as a hydrogel system in tissue regeneration and drug delivery applications. This review summarizes the synthesis methods of these two polymers and the improvements on these methods over the years. The influence of precursor monomers on the physical properties of the synthesized polymer is comprehensively described, along with the cross-linking strategies. The major focus of this review is to highlight the applications of PCLF and OPF over the years in nerve, cartilage, and bone tissue engineering, as well as drug delivery applications. The nano- and micro- composites developed using these polymers to better accommodate the required application especially in cartilage and bone tissue regeneration are explained in detail. Finally, we provide our perspective on future directions for these polymers in regenerative medicine.



中文翻译:

聚(己内酯富马酸酯)和寡聚(聚乙二醇富马酸酯):生物医学应用研究的两个十年

在过去的几十年中,人们对用于生物医学应用的基于富马酸酯的聚合物产生了浓厚的兴趣。聚己内酯富马酸酯(PCLF)和低聚[聚乙二醇富马酸酯](OPF)分别是聚己内酯和聚乙二醇的衍生物,通过引入不饱和富马酸酯可使其交联,可生物降解并具有可调的机械性能。组。PCLF是一种疏水性聚合物,通常用作预成型或3-D印刷支架,而OPF是一种基于水溶剂的聚合物,通常在组织再生和药物输送应用中被视为一种水凝胶体系。这篇综述总结了这两种聚合物的合成方法以及多年来对这些方法的改进。前体单体对合成聚合物物理性能的影响以及交联策略都得到了全面的描述。这篇综述的主要重点是强调多年来PCLF和OPF在神经,软骨和骨组织工程以及药物输送应用中的应用。详细解释了使用这些聚合物开发的纳米和微米复合材料,以更好地适应所需的应用,尤其是在软骨和骨组织再生中。最后,我们对再生医学中这些聚合物的未来发展方向提供了看法。以及药物输送应用。详细解释了使用这些聚合物开发的纳米和微米复合材料,以更好地适应所需的应用,尤其是在软骨和骨组织再生中。最后,我们对再生医学中这些聚合物的未来发展方向提供了看法。以及药物输送应用。详细解释了使用这些聚合物开发的纳米和微米复合材料,以更好地适应所需的应用,尤其是在软骨和骨组织再生中。最后,我们对再生医学中这些聚合物的未来发展方向提供了看法。

更新日期:2020-05-04
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