Euphopanes A–C, three new diterpenoids from Euphorbia pekinensis,Natural Product Research

当前位置： X-MOL 学术 › Nat. Prod. Res. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Euphopanes A–C, three new diterpenoids from Euphorbia pekinensis
Natural Product Research ( IF 2.2 ) Pub Date : 2020-05-13 , DOI: 10.1080/14786419.2020.1765342
Xue-Long Yan ₁ , Jia-Luo Huang ₁ , Ya-Qi Tang ₁ , Gui-Hua Tang ₁ , Sheng Yin ₁

Affiliation

Abstract

Three new diterpenoids, euphopanes A–C (1–3), including one ent-isopimarane (1), one ent-abietane (2) and one cembrane (3), along with five known compounds (4–8) were isolated from the roots of Euphorbia pekinensis. Their structures were elucidated by extensive spectroscopic analysis, and the absolute configurations of compounds 1–3 were determined by ECD calculations. All the isolates were screened for the cytotoxicity against three cancer cell lines (C4-2B, C42B/ENZR, and MDA-MB-231), and compounds 1, 2, and 4 showed significant cytotoxicity against human prostate cancer cells C4-2B with IC₅₀ values of 14.3, 16.9, and 15.3 μM, respectively.

更新日期：2020-05-13

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南

全部期刊列表>>