ABSTRACT

Background: The role of T cell Ig and ITIM domain (TIGIT) and programmed cell death-1 (PD-1) in colorectal cancer (CRC) with mismatch repair deficiency is unknown.

Methods: This was a study of 60 CRC patients with mismatch repair deficiency and 30 healthy controls between June 2015 and October 2015.

Results: The expression of Foxp3, PD-1, and TIGIT was higher in cancer tissues compared with adjacent mucosa (all P < .05). Patients with advanced TNM stage had a significantly higher expression of TIGIT (P = .025) and PD-1 (P = .020) than patients with early-stage CRC. The disease-free survival (DFS) of patients with high TIGIT (HR = 3.96, 95%CI: 1.34–11.69, P = .013) or PD-1 (HR = 214.8, 95%CI: 49.88–925.2, P < .001) expression were better. The overall survival (OS) of the patients with CRC and high expression of PD-1 was worse than those with low expression (HR = 4.01, 95%CI:1.26–12.69, P = .019).

Conclusion: TIGIT and PD-1 are upregulated in CRC with mismatch repair deficiency and associated with TNM stage and DFS.

摘要

背景：T 细胞 Ig 和 ITIM 结构域 (TIGIT) 以及程序性细胞死亡-1 (PD-1) 在错配修复缺陷的结直肠癌 (CRC) 中的作用尚不清楚。

方法：这是一项在 2015 年 6 月至 2015 年 10 月期间对 60 名错配修复缺陷的 CRC 患者和 30 名健康对照者进行的研究。

结果：癌组织中Foxp3、PD-1和TIGIT的表达高于癌旁黏膜（均P < .05）。晚期 TNM 分期患者的 TIGIT ( P = .025) 和 PD-1 ( P = .020)表达显着高于早期 CRC 患者。高 TIGIT（HR = 3.96, 95%CI: 1.34–11.69, P = .013）或 PD-1（HR = 214.8, 95%CI: 49.88–925.2, P < .001) 表达更好。结直肠癌和PD-1高表达患者的总生存期（OS）比低表达患者差（HR = 4.01，95%CI：1.26-12.69，P = .019）。

结论：TIGIT 和 PD-1 在具有错配修复缺陷的 CRC 中上调，并与 TNM 分期和 DFS 相关。