Parathyroid hormone (PTH ) is a crucial regulator of calcium homeostasis and bone remodeling, and the parathyroid hormone 1 receptor (PTH1R ) belongs to a class II G‐protein‐coupled receptor. PTH activates PTH1R , which mediates catabolic and anabolic processes in the skeleton. However, the functional mechanism of PTH1R has not been thoroughly elucidated in organisms. This study identified a 51 bp indel mutation in the first intron of the PTH1R gene and elucidated the effect of this gene mutation on the growth and carcass traits in chickens. The results indicated that the 51 bp indel was significantly associated with subcutaneous fat thickness, abdominal fat weight, body weight and daily gain over 4–8 weeks. Furthermore, we found that PTH1R gene expression was highest in the kidney and liver tissues, and it showed a trend of decreasing in leg and breast muscle tissues at different embryonic stages. In addition, we examined the expression of the three genotypes of the PTH1R gene in the liver, breast muscle and abdominal fat and found that the II genotype was significantly higher than the DD and ID genotypes. In summary, these findings suggest that the PTH1R gene can serve as a potential molecular marker for chicken breeding.

中文翻译：

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PTH1R基因内的51 bp indel多态性与鸡的生长和car体性状显着相关。

甲状旁腺激素（PTH）是钙稳态和骨骼重塑的关键调节剂，甲状旁腺激素1受体（PTH1R）属于II类G蛋白偶联受体。PTH激活PTH1R，后者介导骨骼中的分解代谢和合成代谢过程。但是，PTH1R的功能机制尚未在生物体中彻底阐明。这项研究在PTH1R的第一个内含子中发现了一个51 bp的indel突变基因并阐明了该基因突变对鸡的生长和car体性状的影响。结果表明，在4-8周内，51 bp插入缺失与皮下脂肪厚度，腹部脂肪重量，体重和日增重显着相关。此外，我们发现PTH1R基因在肾脏和肝脏组织中的表达最高，并且在不同的胚胎阶段，其腿部和胸部肌肉组织的表达呈下降趋势。此外，我们检查了PTH1R基因的三种基因型在肝脏，胸肌和腹部脂肪中的表达，发现II型基因型明显高于DD和ID型。基因型。总之，这些发现表明，PTH1R基因可以作为鸡育种的潜在分子标记。