Duloxetine (DLX) is a widely used antidepressant drug belonging to the class of selective serotonin and norepinephrine reuptake inhibitors (SNRIs); its efficacy has been demonstrated in the treatment of not only major depressive disorders but also diabetic neuropathic pain, generalized anxiety disorder, fibromyalgia or stress urinary incontinence. It is a chiral substance and is used in therapy in the form of the enantiopure S‐DLX, which is twice as active as R‐DLX. Several methods have been published for the achiral and chiral determination of DLX in pharmaceuticals, biological materials and environmental samples, the majority using liquid chromatography and capillary electrophoresis coupled with different detection techniques (UV detection, fluorescence, mass spectrometry). The aim of the current review is to provide a systematic survey of the analytical techniques used for the determination of DLX from different matrices.

中文翻译：

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用色谱和电泳方法对度洛西汀进行手性和手性分析，有关分离方法的综述。

度洛西汀（DLX）是一种广泛使用的抗抑郁药，属于选择性5-羟色胺和去甲肾上腺素再摄取抑制剂（SNRIs）类；它的功效不仅可以治疗主要的抑郁症，还可以治疗糖尿病性神经性疼痛，广泛性焦虑症，纤维肌痛或压力性尿失禁。它是一种手性物质，以对映纯S- DLX的形式用于治疗，其活性是R的两倍‐DLX。已公开了几种用于非手性和手性测定药物，生物材料和环境样品中DLX的方法，大多数使用液相色谱和毛细管电泳结合不同的检测技术（紫外检测，荧光，质谱）。本次审查的目的是对用于从不同基质测定DLX的分析技术进行系统的调查。