Collagen-based biomaterials are known to be the most potential and promising materials with diverse applications in tissue engineering and regeneration, due to its excellent biocompatibility. The major drawback of collagen is its rapid degradation, which can be overcome by crosslinking methods. Polyphenols exhibit excellent antioxidant activity and antimicrobial properties. In the present work, polyphenol-treated collagen scaffold (PPCS) was prepared by treating the aqueous extract of the dried ripe fruits of Terminalia chebula with bovine collagen. Scanning electron microscopy (SEM) of PPCS showed highly oriented interwoven fibrillar collagenous bundles in the network form. The chemical structure modification in PPCS was demonstrated by Fourier Transform Infrared spectroscopy. Tensile property and hydrophilicity of the PPCS showed enhanced values compared to the untreated collagen (COL). The thermal properties of COL and PPC scaffolds investigated by thermogravimetric analysis and differential scanning calorimetry, showed increased thermal decomposition and denaturation temperature values for the polyphenol crosslinked collagen. Further, the PPCS exhibited increased resistance to hydrolysis by collagenase. In vitro studies on biocompatibility showed increased fibroblast cell proliferation on PPCS. Thereby, the physico-chemical and biological properties of PPCS identify it as a promising scaffold with high biocompatibility for applications in tissue engineering and regenerative medicine.

基于胶原的生物材料因其出色的生物相容性而被公认为是最有前途的材料，在组织工程和再生中具有多种应用。胶原蛋白的主要缺点是其快速降解，可以通过交联方法克服。多酚具有出色的抗氧化活性和抗菌性能。在本工作中，通过处理Terminalia chebula干燥成熟果实的水提取物来制备多酚处理的胶原蛋白支架（PPCS）。与牛胶原蛋白。PPCS的扫描电子显微镜（SEM）显示呈网络状的高取向交织原纤维胶原束。PPCS中的化学结构修饰已通过傅里叶变换红外光谱进行了证明。与未处理的胶原蛋白（COL）相比，PPCS的拉伸性能和亲水性显示出更高的值。通过热重分析和差示扫描量热法研究的COL和PPC支架的热性能显示多酚交联胶原蛋白的热分解和变性温度值增加。此外，PPCS表现出增加的对胶原酶水解的抗性。体外生物相容性研究表明，PPCS上的成纤维细胞增殖增加。从而，