The Magellan ecoregion, located in the sub-Antarctic portion of Chile, is marked as a continental portion of high latitude that presents low periods of photoperiod and luminosity in the winter and high in the summer. Seasonal variations in the chemical composition of seaweeds may influence their reproductive state and biomass, and thus their prospection into food, cosmetological or pharmacological use. The objectives of the present study were to determine the fatty acids (FAs) profile of the red seaweed Mazzaella laminarioides in vegetative, tetrasporophitic, and cystocarpic phases in winter and summer, and assess the antitumoral activity of these FAs against T24 bladder cancer cells. The algal extracts consisted of nineteen FAs, and composition varied according to the reproductive state and the season the algae were collected. Cell viability decreased in a concentration- and time-dependent manner. Most significant cytotoxic activity of FAs, as well as the highest chromatin condensation observed by DAPI staining was at a concentration of 200 μg/mL in 24 and 48 h. The results indicate that FAs derived from M. laminarioides have potential to reduce the proliferation in BC cells.

麦哲伦（Magellan）生态区位于智利的南极子地区，被标记为高纬度的大陆部分，在冬季呈现出低水平的光周期和光度，而夏季则呈现出高水平。海藻化学成分的季节性变化可能会影响其繁殖状态和生物量，进而影响其在食品，美容或药理学用途中的前景。本研究的目的是确定红海藻Mazzaella laminarioides的脂肪酸（FAs）谱在冬季和夏季处于营养期，四孢子期和囊果期，并评估这些FA对T24膀胱癌细胞的抗肿瘤活性。藻类提取物由19种FA组成，其组成随繁殖状态和藻类采集季节而变化。细胞活力以浓度和时间依赖性方式降低。FAs最显着的细胞毒性活性以及DAPI染色观察到的最高染色质浓缩在24和48小时内浓度为200μg/ mL。结果表明，源自M. laminarioides的FA具有降低BC细胞增殖的潜力。