INTRODUCTION Effectiveness of mechanical thrombectomy for mild-deficit stroke due to large-vessel occlusion is controversial. We present a single-center consecutive case series on thrombectomy for large-vessel occlusion mild stroke. We evaluated various thrombectomy parameters to better understand disagreement in the literature. METHODS Data from a retrospective cohort of large-vessel occlusion mild stroke patients (National Institutes of Health Stroke Scale <6) treated with mechanical thrombectomy over 6 years and 2 months were analyzed. Patients were divided into 2 groups: successful reperfusion (modified Thrombolysis in Cerebral Infarction 2b or 3) and failed reperfusion (modified Thrombolysis in Cerebral Infarction 0,1, or 2a). Ninety-day modified Rankin Scale in-hospital mortality, and symptomatic hemorrhage rates were compared between groups. Multivariate logistic regression was performed to evaluate reperfusion status as a predictor of 90-day favorable (modified Rankin Scale 0-2) and excellent (modified Rankin Scale 0-1) outcomes. RESULTS We identified 61 patients with large-vessel occlusion mild stroke who underwent thrombectomy. Reperfusion was successful in 49 patients and a failure in 12. The successful group exhibited significantly higher rates of favorable outcome (83.7% vs. 25.0%; p < 0.001) and excellent outcome (69.4% vs.16.7%; p = 0.002) at 90 days. In-hospital mortality was significantly higher in the failure group (41.7% vs.10.2%; p = 0.019). Multivariate logistic regression identified successful reperfusion as a significant predictor (p = 0.001) of 90-day favorable outcome. CONCLUSION Reperfusion success was significantly associated with improved functional outcomes in large-vessel occlusion mild stroke mechanical thrombectomy. Future studies should consider reperfusion rates when evaluating the effectiveness of thrombectomy against that of medical management in these patients.

中文翻译：

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血管内再灌注对美国国立卫生研究院卒中量表评分低大血管闭塞性中风的影响。

引言机械血栓切除术对因大血管闭塞引起的轻度卒中的有效性尚存争议。我们为大血管闭塞性轻度卒中的血栓切除术提出了一个单中心连续病例系列。我们评估了各种血栓切除术参数，以更好地理解文献中的分歧。方法分析回顾性队列研究的大血管闭塞轻度卒中患者（美国国立卫生研究院卒中量表<6）接受机械血栓切除术治疗6年和2个月的数据。患者分为两组：成功的再灌注（改良的脑梗塞溶栓治疗2b或3）和失败的再灌注（改良的脑梗塞溶栓治疗0,1或2a）。九十天改良兰金量表住院死亡率，比较两组之间的症状性出血发生率。进行多因素logistic回归以评估再灌注状态，作为90天有利（改良Rankin量表0-2）和优秀（改良Rankin量表0-1）的预测指标。结果我们确定了61例接受了血栓切除术的大血管闭塞性轻度卒中患者。再灌注成功49例，失败12例。成功组显示良好的预后率（83.7％vs. 25.0％； p <0.001）和优异的预后率（69.4％vs. 16.7％； p = 0.002） 90天。衰竭组的院内死亡率显着更高（41.7％vs. 10.2％； p = 0.019）。多因素逻辑回归分析表明，成功的再灌注是90天良好预后的重要预测指标（p = 0.001）。结论在大血管阻塞轻度卒中机械血栓切除术中，再灌注成功与功能预后的改善显着相关。在评估这些患者血栓切除术相对于药物治疗的有效性时，未来的研究应考虑再灌注率。